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Thyroid: Thyroid disease affects how much or how little hormone the thyroid glands produce. Hormones produced by the thyroid gland help control metabolism. The glands do not create enough hormones when one has hypothyroidism. Fatigue, sensitivity to the cold, weight gain, constipation, depression, sluggishness of movement and thought, and muscle pains, weakness, or cramping are all signs of hypothyroidism. Although there is no cure as of now, you can control this