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Fibrin, or factor Ia, is a protein essential in the clotting of blood. It is formed from fibrinogen, a protein present in blood. When there is an injury to a blood vessel the platelets in the blood adhere to the damaged vessel wall to form a platelet plug. Thrombin, a clotting enzyme, converts fibrinogen in the blood serum into fibrin. A complex series of events is activated to form a clot which consists of a fibrin mesh around the platelet plug.   Liver disease can cause deficient, absent or defective fibrin leading to clotting disorders like dysfibrinogenaemia, afibrinogenaemia, haemophilia, etc. predisposing to haemorrhage (bleeding). Excessive fibrin production causes thrombosis (obstructive clotting).


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