Preeclampsia

Most babies born to women with preeclampsia are healthy; however, if the condition is left treated, it could lead to complications for both the mother and foetus.

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What Is Preeclampsia?

Preeclampsia, a serious condition that can occur after the 20th week of pregnancy, occurs in about 2%–8% of pregnancies worldwide. A woman with preeclampsia has high blood pressure, has protein in her urine and may have swellings in her hand, face, legs or full body. If blood pressure is high, it can cause problems during pregnancy and cause stress to your heart. Doctors are still not aware of the exact cause behind preeclampsia. They assume that it is caused by the placenta not properly attaching to the uterine wall in the first trimester. This causes the blood vessels in the entire body to become narrower, which in turn increases the blood pressure. Moreover, the blood vessels do not properly supply to the foetus and placenta, thus depriving the foetus of essential nutrients and oxygen.

Symptoms

The preeclampsia-related symptoms include the following:


  • Persistent headaches

  • Swelling in hands and face

  • Pain in the upper part of the abdomen or shoulders

  • Changes in eyesight or seeing spots

  • Sudden increase in weight 

  • Nausea and vomiting in the second half of your pregnancy 

  • Breathing difficulty


You should immediately call your doctor if you notice any of these symptoms in the second half of your pregnancy. 

If your preeclampsia worsens, you could have “severe problems,” including: 

  • Changes in your vision

  • Decreased platelets in your blood

  • Pain in the upper abdomen

  • Abnormal liver or kidney function 

  • Severe headache

  • Systolic pressure of at least 16 mm Hg or diastolic pressure of at least 110 mm Hg

  • Fluid build-up in lungs 

Causes And Risk Factors

Causes

If placental development is not normal in the first trimester, the placenta will not be able to sufficiently provide for the foetus and will lead to the mixing up of the placental material with the mother’s blood circulation. The pregnant mother will then develop high blood pressure, kidney problems and have protein in her urine. The mother will be at risk for HELLP syndrome (a condition in which her platelet count decreases, liver function enzymes are elevated, and her red blood cells are destroyed). Moreover, she will be at risk for eclampsia (a life-threatening condition in which the pregnant woman has seizures or may go into a coma) and other organ damage. 

Scientists still do not know the exact cause of preeclampsia, which is thought to be caused by the faulty functioning of the placenta; it may include insufficient blood flow to the placenta also. 

Risk Factors

The exact reason for developing preeclampsia is unclear. You may either be at high risk or moderate risk of developing preeclampsia. 

Some risk factors for the moderate risk of developing preeclampsia are listed below:


  • Being older than 35 years

  • Family history of preeclampsia 

  • First pregnancy

  • Having a body mass index of >30


Some risk factors for high risk of developing preeclampsia are as follows:

  • Kidney disease

  • Chronic hypertension

  • Preeclampsia in a previous pregnancy

  • Diabetes mellitus

  • Carrying more than one foetus in the womb

  • Autoimmune conditions, including lupus

Prevention

Preeclampsia can be prevented by avoiding pregnancy if you have a high risk of preeclampsia, improving nutrition and modifying lifestyle. 

Some of the ways preeclampsia can be prevented include:


  • Exercise: Physical activity and exercise regularly help reduce high blood pressure in non-pregnant women and may help prevent preeclampsia.

  • Salt intake: Reducing your salt intake helps control your blood pressure.

  • Water: You should drink at least 6–8 glasses of water every day.

  • Rest: Rest is important and you should get sufficient rest. 

  • Food: Try to avoid unhealthy junk and fried foods. 

  • Drinks: Avoid drinking alcohol and caffeinated beverages. 

  • Elevating your feet: When you rest, do keep your feet at an elevated position. 

  • Medications: You may require to have certain medicines and supplements that your doctor prescribes. 

Diagnosis

The diagnosis of preeclampsia is based on the following:


  • Blood pressure: The first sign of preeclampsia is an increase in blood pressure. To confirm the results, your blood pressure reading will be taken more than once. 

  • Urine test: You will have a urine test to check for the presence of proteins. 

  • Blood tests: Blood tests may be performed to determine if your kidney and liver are properly functioning. The platelet count in your blood sample will be measured.

  • Ultrasound: An ultrasound may be performed to check if your baby is doing alright and seeing the placenta and fluid around your baby to determine if your pregnancy is healthy. 

  • Nonstress test: A test to determine your baby’s heart rate may be performed. 

Treatment

If you have mild preeclampsia after 37 weeks of pregnancy, there are usually no major health complications. If your condition is stable after 37 weeks, your doctor may suggest delivering the baby early to prevent any harm to you and your baby. The doctor will give you medicine to induce labour; you can then deliver your baby.
For mild preeclampsia before 37 weeks, your doctor will closely monitor your condition. Your blood pressure and urine tests will be regularly performed. You may be admitted to the hospital to be under observation if required. If you do not require to be admitted, you will have to visit your doctor twice or thrice a week for check-ups. You may require to check your blood pressure at home.
Your doctor may ask you to do kick counts, i.e., count the number of times your baby moves. You can do this by checking how long it takes for your baby to move ten times each day. If the number changes with each hour or if your baby takes > 2 h to move ten times, inform your doctor.
If you have severe preeclampsia, you will require to be admitted to the hospital. You may be given antenatal corticosteroids to help your baby’s lungs develop faster. You may get medicines to control your blood pressure and prevent any seizure. If your condition does not improve, you may require to deliver your baby. If you are 34 weeks pregnant and stable, your doctor may induce labour or deliver your baby via caesarean section (c-section). If you are not 34 weeks pregnant and you and your baby’s condition has stabilised, you may be able to wait for some time before delivery.

Lifestyle/management

Some self-care ways to control and prevent preeclampsia include:


  • Be regular in your health check-ups and take all prescribed medicines and supplements as advised. 

  • Take the prescribed vitamin D, folate, antioxidants and calcium.

  • If you have anaemia, you may require treatment for it. 

  • Use less salt in your diet, avoid cold and frozen food, alcohol and drinks with caffeine and reduce your intake of fried foods, salty foods and processed meats. 

  • Increase your intake of fruits, vegetables and vegetable oils.

  • Do not lead a very sedentary life. Perform exercises, stretches, go for walks, or use the stationary bicycle. 

  • Try to reduce any stressful situations, including in your professional and personal life. You may perform yoga to reduce stress and relax. 

Prognosis And Complications

Prognosis

In most cases, a complete recovery from preeclampsia is the norm. Your blood pressure should start improving one to two days after you deliver; within the next six weeks, your blood pressure should be back to what it was before pregnancy. However, certain women may have complications. 

If you had preeclampsia in your first pregnancy, there is a one in five chance that you will have it in your second pregnancy. The risk is even higher if you had severe or early preeclampsia or if you have a medical condition such as diabetes or high blood pressure. 

If you had preeclampsia, you have a risk of developing cardiovascular diseases later. Thus, you should adopt a healthy lifestyle to lower this risk. 

Complications

If preeclampsia is left untreated, it could lead to complications for the mother and the baby and may lead to death too. 

Some possible complications for the mother include:


  • Problems with clotting of your blood, leading to serious bleeding problems

  • Damage to the kidney, liver and brain

  • Eclampsia 

  • Stroke (decreased oxygen supply to the brain because of blockage or bursting of a blood vessel)


Some complications that may occur during pregnancy include:

  • Low birthweight 

  • Premature birth (you may need to give birth to your baby early)

  • Intrauterine growth restriction (the foetus has poor growth because of the narrowing of the blood vessels in the placenta and uterus, which causes the restricted supply of food and oxygen to the foetus) 

  • Placental abruption (the partial or complete separation of the placenta from the uterus wall before the birth of the baby, causing the foetus to not get sufficient food and oxygen)

  • Increased risk of postpartum haemorrhage (heavy bleeding after birth that can lead to death)


It increases the risk of developing diabetes, kidney disease and cardiovascular diseases later in the mother’s life. 

References

 Harvard Health Publishing. Preeclampsia and eclampsia [Internet][Updated on Oct, 2018]. Available at: https://www.health.harvard.edu/a_to_z/preeclampsia-and-eclampsia-a-to-z. Accessed on May 11, 2021. (https://www.health.harvard.edu/a_to_z/preeclampsia-and-eclampsia-a-to-z)

2. March of Dimes. Preeclampsia [Internet][Updated on Oct, 2020]. Available at: https://www.marchofdimes.org/complications/preeclampsia.aspx. Accessed on May 11, 2021. (https://www.marchofdimes.org/complications/preeclampsia.aspx)

3. Hladunewich M, et al. Clin J Am Soc Nephrol. 2007 May;2(3):543-9.

4. American College of Obstetricians and Gynecologists. Preeclampsia and high blood pressure during pregnancy [Internet][Updated on Dec, 2020]. Available at: https://www.acog.org/womens-health/faqs/preeclampsia-and-high-blood-pressure-during-pregnancy. Accessed on May 11, 2021. (https://www.acog.org/womens-health/faqs/preeclampsia-and-high-blood-pressure-during-pregnancy)

5. American Pregnancy Association. Preeclampsia [Internet][Updated on Sep 20, 2020]. Available at: https://americanpregnancy.org/healthy-pregnancy/pregnancy-complications/preeclampsia-927/. Accessed on May 11, 2021. (https://americanpregnancy.org/healthy-pregnancy/pregnancy-complications/preeclampsia-927/)

6. Moura SB, et al. J Pregnancy. 2012; 2012: 435090.

7. Rasouli M, et al. Int J Prev Med. 2019; 10: 21. 

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