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Children born to mothers who had diabetes during pregnancy may age faster

After about 20 weeks of pregnancy, the fetus’ kidneys begin producing most of the amniotic fluid.

Gestational diabetes may accelerate a child's biological age and increase his/her risk for obesity and high blood pressure later in life.

Written by Longjam Dineshwori |Updated : September 15, 2020 1:07 PM IST

During pregnancy, some women develop high blood sugar levels. This condition is known as gestational diabetes mellitus (GDM) and it usually disappears after giving birth. Untreated gestational diabetes can cause premature birth and stillbirth. It can also cause problems for mothers and babies in the long term. The elevated blood glucose level during pregnancy can put your child at a higher risk of developing obesity and type 2 diabetes later in life. Children born to mothers who had diabetes during pregnancy may age faster biologically, said a new study published in the journal Epigenetics.

The study also linked gestational diabetes to increased risk for obesity and high blood pressure.

Accelerated aging may lead to poor health outcomes

For the findings, the authors explored how more than 1,000 children born to mothers in Tianjin, China aged on a cellular level. They measured the DNA methylation age, or epigenetic age, of the children who were ages 3 to 10 to see how it differed from their chronological age.

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Accelerated aging, which is when a person's estimated DNA methylation age is greater than their chronological age, has been found to be associated with cardiovascular risks and poor health outcomes later in life.

The researchers found that children born to mothers who had gestational diabetes had a higher epigenetic age -- or were "older" than their actual age. The epigenetic age was also associated with higher weight, body mass index, body fat percentage, upper-arm circumference and blood pressure.

Based on these findings, the researchers suggest that gestational diabetes may have long-term effects on epigenetic aging in offspring and lead to poorer cardiometabolic health outcomes.

Symptoms & Causes of Gestational Diabetes

Gestational diabetes is estimated to affect around 7 10% of all pregnancies worldwide. There are two classes of gestational diabetes: class A1 and class A2. While class A1 can be managed through diet and exercise, class A2 may require pregnant women to take insulin or other medications.

Women with gestational diabetes usually don't experience symptoms or they may be confused with pregnancy symptoms. Gestational diabetes is often diagnosed during routine screening. If you have a high blood sugar level, you may feel thirstier and hungrier than usual and pee more than usual.

Hormones released by your placenta during pregnancy can cause glucose to build up in your blood. Insulin, a hormone produced by your pancreas, helps your body use glucose for energy and helps control your blood glucose levels. But if the pancreas doesn't make enough insulin or the body's cells can't use insulin as it should, the blood sugar levels will rise, and thus you get gestational diabetes.

Some women are more likely to get gestational diabetes. These include those who were overweight before getting pregnant, who have prediabetes, have a family member with diabetes, have had gestational diabetes before or who are older than 25.

You are more likely to develop gestational diabetes in the second half of pregnancy. Gestational diabetes should be treated as soon as possible to keep yourself and your baby healthy during your pregnancy and delivery. Eat a healthy diet and exercise throughout your pregnancy to keep your blood sugar under control.

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