High Cholesterol Side Effects: 5 Things That Can Happen In Your Body When LDL Level Rises

High cholesterol can lead up to building plaque on the walls of your arteries, which is a type of blood vessel. When this small valves are blocked it can trigger serious health conditions.

Written by N. Lothungbeni Humtsoe | Published : September 15, 2025 10:00 AM IST

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What Happens Plaque Buildup

"As plaque builds up over time, the insides of your arteries narrow. This narrowing blocks blood flow to and from your heart and other organs," the Center for Disease Control and Prevention (CDC) explained.

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Peripheral Artery Disease (PAD)

High cholesterol levels can also build up plaque in the arteries of your limbs, especially in your feet and legs. This condition is known as Peripheral Artery Disease (PAD), which reduces blood flow in your peripheral arteries.

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When your LDL level rises, it also increases the risk of stroke. This occurs when the buildup of plaque interrupts the supply of blood to the brain.