Jahnavi Sarma
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Childhood trauma can lead to not only mental health outcomes like depression and anxiety, but also physical health outcomes like cardiovascular disease, diabetes and cancer. @Shutterstock
Kids are resilient, no doubt, but any kind of trauma during childhood can have a lifelong effect on them. Early intervention is essential to prevent these scars from festering into adulthood. According to a new study at Harvard University, children who suffer trauma from abuse or violence early in life show biological signs of aging faster than children who have never experienced adversity. Researchers examined three different signs of biological aging - early puberty, cellular aging and changes in brain structure - and found that trauma exposure was associated with all three.
According to researchers, exposure to adversity in childhood is a powerful predictor of health outcomes later in life. It includes not only mental health outcomes like depression and anxiety, but also physical health outcomes like cardiovascular disease, diabetes and cancer. Experiencing violence can make the body age more quickly at a biological level, which may help to explain the connection.
Earlier studies found mixed evidence on whether childhood adversity is always linked to accelerated aging. However, those studies looked at many different types of adversity like abuse, neglect, poverty and more. In the new study, researchers looked separately at two categories of adversity: threat-related adversity, such as abuse and violence, and deprivation-related adversity, such as physical or emotional neglect or poverty.
The researchers performed a meta-analysis of almost 80 studies, with more than 116,000 total participants. They found that children who suffered threat-related trauma such as violence or abuse were more likely to enter puberty early and also showed signs of accelerated aging on a cellular level-including shortened telomeres, the protective caps at the ends of our strands of DNA that wear down as we age. However, children who experienced poverty or neglect did not show either of those signs of early aging.
In a second analysis, researcher systematically reviewed 25 studies with more than 3,253 participants that examined how early-life adversity affects brain development. They found that adversity was associated with reduced cortical thickness - a sign of aging because the cortex thins as people age. However, different types of adversity were associated with cortical thinning in different parts of the brain. Trauma and violence were associated with thinning in the ventromedial prefrontal cortex, which is involved in social and emotional processing, while deprivation was more often associated with thinning in the frontoparietal, default mode and visual networks, which are involved in sensory and cognitive processing.
These types of accelerated aging might originally have descended from useful evolutionary adaptations. In a violent and threat-filled environment, for example, reaching puberty earlier could make people more likely to be able to reproduce before they die. And faster development of brain regions that play a role in emotion processing could help children identify and respond to threats, keeping them safer in dangerous environments. But these once-useful adaptations may have grave health and mental health consequences in adulthood.
The new research underscores the need for early interventions to help avoid those consequences. All of the studies looked at accelerated aging in children and adolescents under age 18. Researchers say that the biological mechanisms that contribute to health disparities are set in motion very early in life. This means that efforts to prevent these health disparities must also begin during childhood. There are numerous evidence-based treatments that can improve mental health in children who have experienced trauma. A critical next step is determining whether these psychosocial interventions might also be able to slow down this pattern of accelerated biological aging. If this is possible, it may be possible to prevent many of the long-term health consequences of early-life adversity.
(With inputs from Agencies)