In one out of 100000 infants a mutation in the GALC gene causes an incurable and fatal disorder known as infantile Krabbe disease. It may also be known as globoid cell leukodystrophy. Most children with the condition die before they turn 2. A parallel condition also naturally affects dogs who typically show symptoms of the disease at six weeks old and succumb to it within a few months. A new study in the Journal of Clinical Investigation (JCI) led by the School of Veterinary Medicine's Charles Vite describes an effective gene therapy for Krabbe disease in dogs with lasting impact.