Switch to हिंदी

Health, Fitness, Beauty & Diet | Pregnancy & Parenting | Diseases & Home Remedies | TheHealthSite.com

Health, Fitness, Beauty & Diet | Pregnancy & Parenting | Diseases & Home Remedies | TheHealthSite.com

हिंदी
  • Health A-Z
  • Home Remedies
  • Diseases
    • Type 1 Diabetes
    • Type 2 Diabetes
    • Cancer
    • Heart Attack
    • Pneumonia
    • Diseases A-Z
  • Diet & Fitness
    • Weight Management
    • Exercise & Body Building
    • Diet & Recipes
    • Yoga
  • Coronavirus
  • News
  • Pregnancy
    • Conceiving
    • Infertility
    • Labour & Delivery
    • Pregnancy week-by-week
    • Breastfeeding
    • Baby Names
  • Beauty
    • Skin
    • Hair
    • Grooming
  • Photos
  • Videos
Home / Health News / Study discovers how diabetes leads to vascular disease

Study discovers how diabetes leads to vascular disease

According to a study published in the journal of Clinical Investigation, high blood glucose activates an enzyme known as protein kinase A (PKA), which increases calcium channel activity and constricts blood vessels.

By: ANI   | | Published: July 22, 2019 10:40 am
Tags: High blood sugar  
diabetes
Diabetes is a condition that impairs the body's ability to process blood glucose. © Shutterstock

A team of scientists and physicians identified a cellular connection between diabetes and one of its major complications – narrowing of the blood vessel – which increases risks of several serious health conditions, including heart disease and stroke. Also Read - Blood glucose level should be considered as ‘fifth vital sign’ during hospitalization: Indian docs

The same team previously found that high blood glucose, the hallmark symptom of diabetes, activates an enzyme known as protein kinase A (PKA), which increases calcium channel activity and constricts blood vessels. Also Read - Blood sugar spike due to COVID-19 could kill even non-diabetics



“This was a surprise since PKA is typically associated with blood vessel widening and wasn’t really on our radar. We wanted to understand the molecular processes that created this opposite reaction,” said senior author Manuel Navedo.

For the new study, published in the journal of Clinical Investigation, the team conducted a series of experiments on the effects of high glucose on cerebral blood vessels and arterial cells that control blood flow. The tests were conducted on a unique genetically modified mouse and two mouse models of diabetes that were developed for studies of cardiovascular health. Also Read - Are you a diabetic? 5 things you should do every morning to control blood sugar levels

The researchers focused on the relationship between PKA and adenylyl cyclase (AC), an enzyme involved in cyclic AMP (cAMP) production, a cellular messenger with a critical role in vascular cell function.

Their results showed that one AC in particular, AC5 mediated cAMP and PKA activation, triggering increased calcium channel activity and blood vessel narrowing. They also found that AC5 was essential for blood-vessel constriction during diabetes.

The team now hopes to test the effects of the AC5 chain reaction in high-glucose conditions in human cells. This step could confirm it as a treatment target for reducing the vascular complications of diabetes, which can include eye, kidney, and cerebral, gastrointestinal and cardiovascular disease.

“We see every day in our clinics the devastating impact of diabetes on the health and lives of our patients. Our work brings into much clearer focus on how high glucose can damage the vascular system and gives us a new target for blocking its effects,” said co-author Nipavan Chiamvimonvat.

Published : July 22, 2019 10:40 am
Read Disclaimer

Neurons help in reducing seizures in newborns: Study

Neurons help in reducing seizures in newborns: Study

AI predicts long-term mortality from chest X-ray data

AI predicts long-term mortality from chest X-ray data

Please Wait. Article Loading ....

Coronavirus Updates

Coronavirus Updates

Stay Informed, Be Safe

  • This monoclonal antibody 'cocktail' may block COVID variants: Study
  • 85-year-old Dalai Lama gets first dose of COVID vaccine
  • Maharashtra records over 10,000 new coronavirus cases, highest since October
  • 101-year-old woman receives first dose of COVID-19 vaccine jab in Delhi
  • COVID-19 vaccine: Avoid taking these medicines before getting the jab

Health Calculators

BMI Calculator
bmi Calculator
Ideal Body Weight
ideal body weight
Daily Calorie Intake
Daily calorie intake
Calories Burned
calories burned

Related Stories

Blood glucose level should be considered as ‘fifth vital sign’ during hospitalization: Indian docs

Blood glucose level should be considered as ‘fifth vital sign’ during hospitalization: Indian docs

Diabetes: Handful of these nuts can help you manage blood sugar levels

Diabetes: Handful of these nuts can help you manage blood sugar levels

Diabetes: Not just sugar, stay away from these foods to keep diabetes at bay

Diabetes: Not just sugar, stay away from these foods to keep diabetes at bay

Blood sugar spike due to COVID-19 could kill even non-diabetics

Blood sugar spike due to COVID-19 could kill even non-diabetics

Enhance Your Quality of Life with Dabur GlycoDab

Enhance Your Quality of Life with Dabur GlycoDab

Health News in Hindi

3 से 5 रुपये में मिलने वाली इन 4 चीजों से हटाएं चेहरे के तिल, जानें तिल को हटाने का सबसे सस्ता तरीका

गूंथे हुए आटे से रोटी-परांठा बनाने का मन ना करें, तो बनाएं ये 5 खास डिश, स्वाद के साथ बनेगी सेहत भी

Blood in Stool: बड़ी आंत में इस परेशानी की वजह से मल में आता है खून, ये 3 तरीके खून आने से रोकेंगे

कोरोना वैक्सीन लगवाने के बाद बुखार, दर्द और गले में खराश? पिएं ये चीज और पाएं झट से आराम

Walking mistakes: चलते हुए इन 4 कारणों से होता है कूल्हे में दर्द, दर्द होने पर करें ये काम

Read All

Recent Posts

  • Vegan diet may lead to poorer bone health: Boost your calcium and protein intake with these foods
  • Ebola virus kills 13 in two African countries: How it spreads to humans
  • Phase 3 trial in India shows arthritis drug can reduce death risk in severe COVID patients
  • Wildfire smoke several times more harmful to human health than car exhaust: Experts
  • India vaccinates 11.6L people against COVID-19 on Saturday, highest single-day vaccination

About The health Site

TheHealthSite.com is India's largest health site with more than 40 lakh unique visitors per month. We focus on fitness, beauty, health, pregnancy and more.

Most popular health and wellness website in India in 2012 at the Website of the year awards.

health@corp.india.com
+91 – 22 – 6697 1234
Landline Phone number 91 – 22 – 2490 0302.

ZEE ENTERTAINMENT ENTERPRISES LTD, 18th floor, A-Wing, Marathon Futurex, N. M. Joshi Marg, Lower Parel, Mumbai, Maharashtra 400013.

Useful Links

  • Weight Loss
  • Keto Diet Tips
  • Skin Care Tips
  • Intermittent Fasting
  • Apple Cider Vinegar
  • Ashwagandha
  • Cancer
  • Pneumonia
  • Diarrhoea
  • Dengue
  • Typhoid
  • Tuberculosis
  • Chickenpox
  • Chikungunya
  • Depression
  • Hepatitis
  • Diabetes
  • Type 2 diabetes
  • Arthritis
  • Swine Flu
  • Baby Names
  • Cough and cold
  • Heart Attack
  • Breast Cancer
  • Ebola Virus
  • Dengue
  • Malaria
  • International Yoga Day
  • Hypotension
  • Heart Failure
  • Asthma
  • Brain Tumour
  • Celebrity Fitness
  • Goitre
  • HIV/AIDS

We respect your privacy

  • Disclaimer
  • Privacy Policy
  • Contact Us
  • Author Profiles

Copyright © 2021 Zee Entertainment Enterprises Limited. All rights reserved.