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Written By: Editorial Team | Published : June 2, 2014 11:35 AM IST
25 percent of smokers who carry a defect in the BRCA2 gene would be developing lung cancer at some point in their lifetime, a large-scale, international study reveals.
The defect in BRCA2 - best known for its role in breast cancer - increases the risk of developing lung cancer by about 1.8 times.
The researchers, led by a team at The Institute of Cancer Research, London, compared the DNA of 11,348 Europeans with lung cancer and 15,861 without the disease, looking for differences at specific points in their DNA. The team was mainly funded by the US National Institute of Health, with additional support from Cancer Research UK.
The link between lung cancer and defective BRCA2 - known to increase the risk of breast, ovarian and other cancers - was particularly strong in patients with the most common lung cancer sub-type, called squamous cell lung cancer. The researchers also found an association between squamous cell lung cancer and a defect in a second gene, CHEK2, which normally prevents cells from dividing when they have suffered damage to their DNA.
The results suggest that in the future, patients with squamous cell lung cancer could benefit from drugs specifically designed to be effective in cancers with BRCA mutations. A family of drugs called PARP inhibitors have shown success in clinical trials in breast and ovarian cancer patients with BRCA mutations, although it is not known whether they could be effective in lung cancer.
The study has been published in the journal Nature Genetics.
Smoking refers to the inhalation of smoke from various sources like cigarettes, cigars, beedis, pipes or hookahs. The nicotine in tobacco is very addictive and it kills more people than all other recreational drugs put together. The habit is linked to a variety of diseases, including cancer. In fact one out of three cancer cases is caused due to tobacco use. It is the biggest avoidable cause of death in the world and along with alcohol, junk food and a sedentary lifestyle, the main cause for the rise in lifestyle diseases like diabetes, hypertension and cardiovascular ailments. (Read more about... 10 reasons smoking is bad for you)
Want to quit? Here are some great ways to do just that
Cold Turkey The oldest and most successful method is going 'cold turkey' that is quitting smoking without taking any substitute for nicotine. 75% people who've quit smoking claim to have done so without the aid of any aid or supplement. Coupled with therapy and intervention cold turkey is supposed to be the best way to quit. There are various websites and helplines which help people quit without the aid of any medicines. Most replacement therapies look to chemically substitute the nicotine hit of smoking but it just means switching from one addiction to another. One of the champions of cold turkey was Allen Carr, a chain smoker who quit smoking and went on to write a book entitled The Easy Way to Quit Smoking which is the most popular book on quitting smoking in the world. Many people have quit smoking after reading his book and this list include celebrities like Ashton Kutcher, Britney Spears, Richard Branson, Anthony Hopkins and closer home Mahesh Babu and Hrithik Roshan. Allen Carr's basic principle was despite overwhelming evidence which points out the hazards of smoking people don't quit because they think of quitting as 'giving in' or giving up.
Nicotine Replacement Therapies (NRT) NRT looks to take care of nicotine craving by providing a substitute source without the harmful effects of tobacco. It works on the principle that though nicotine is the 'addictive' part of cigarettes the more dangerous ones are tar, carbon monoxide and other gases. There are various products under this Nicorette umbrella which look to aid cessation including chewing gums, lozenges, nasal sprays, patches and inhalers. Some electronic cigarettes also have nicotine filters. Real world studies have shown that NRT's aren't as effective as pharmaceutical companies claim. In the real world, 95% who have taken OTC medication have relapsed.
Other medical aid Several other companies have come out with smoking cessation drugs that don't look to replace nicotine. One such drug is Bupripion which is marketed as an anti-depressant, smoking cessation drug and anti-obesity pill. It works on the principle that smoking is a form of countering depression and an antidepressant can perform the same function. Another popular drug is Pfizer's Varenicline which reduces cravings by making the effects of nicotine less pleasurable. There are various side-effects of these drugs. Varenicline is known to cause suicidal thoughts, depression, drowsiness, nausea and the USFDA even claimed that it can cause cardiovascular disease.
With inputs from ANI
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