Supercharging the mutation rate in cancer cells can create a powerful vaccine that is able to boost the effectiveness of immunotherapy says a major new study. Scientists forced cancer cells in the lab to evolve much more rapidly than usual using a molecule called APOBEC3B which is often used by tumours to drive rapid genetic change and drug resistance. These highly mutated cancer cells could be used to create a vaccine for each individual cancer type which amplified the effects of immunotherapy - and cured mice with a variety of otherwise treatment-resistant tumours showed the study published in the journal