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How many times do you scratch your cuts and wounds? Many isn't it? Yes, cuts and wounds take a long time to heal and meanwhile the itchiness can drive you crazy. Constantly fiddling with your wounds extend their healing time. To put an end to your misery, scientists have now developed a new therapy that will heal your everyday cuts and wounds in half the time. (Read: Protein found in tilapia fish can heal skin wounds )
Scientists at the Albert Einstein College of Medicine of Yeshiva University successfully tested this therapy in mice. 'We envision that our nanoparticle therapy could be used to speed the healing of all sorts of wounds, including everyday cuts and burns, surgical incisions, and chronic skin ulcers, which are a particular problem in the elderly and people with diabetes,' said study co-leader David Sharp, professor of physiology & biophysics at Einstein. The researchers discovered that an enzyme called fidgetin-like 2 (FL2) puts the brakes on skin cells as they migrate towards wounds to heal them. (Read:Sweat glands help heal skin wounds?)
They reasoned that the healing cells could reach their destination faster if their levels of FL2 could be reduced. So they developed a drug that inactivates the gene that makes FL2 and then put the drug in tiny gel capsules called nanoparticles and applied the nanoparticles to wounds on mice. The treated wounds healed much faster than untreated wounds.
FL2 belongs to the fidgetin family of enzymes, which play varying roles in cellular development and function. To learn more about FL2's role in humans, Sharp suppressed FL2's activity in human cells in tissue culture. When those cells were placed on a standard wound assay (for measuring properties like cell migration and proliferation), they moved unusually fast. 'This suggested that if we could find a way to target FL2 in humans, we might have a new way to promote wound healing,' Sharp said.
The study was published online in the Journal of Investigative Dermatology.
With inputs from IANS
Image source: Getty Images
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