Editorial Team
... Read More
By clicking “Accept All Cookies”, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Cookie Policy.
There could soon be a treatment for intrahepatic cholangiocarcinoma (iCCA), the second most common form of liver cancer, as researchers have have now found how two genetic mutations in liver cells may drive tumour formation in iCCA. Two mutant proteins IDH1 and IDH2 are linked to cancer, the findings showed. 'iCCA is resistant to standard treatments like chemotherapy and radiation,' said contributing author Josep Maria Llovet from Icahn School of Medicine at Mount Sinai in the US. (Read: 9 tips to prevent liver disease (Gallery))
'Our findings provide novel insights into the development of iCCA and offers a possible treatment option for patients suffering from this fatal disease,' Llovet added. Past studies have found IDH mutations to be among the most common genetic differences seen in patients with iCCA, but how they contribute to cancer development was unknown going into the current effort. iCCA strikes bile ducts, tube-like structures in the liver that carry bile, which is required for the digestion of food. With so much still unknown about the disease, there is no first-line, standard of care and no successful therapies. (Read: Liver disease an emerging epidemic in India)
The researchers demonstrated that the expression of mutant IDH in the adult liver of genetically engineered mice impairs liver cell development and liver regeneration - a process in which the liver responds to injury - and increases the number of cells to form a tumour. Moreover, mutant IDH were found to work with activated KRAS, a gene essential in cancer development, causing the development of premalignant lesions and a progression to metastatic iCCA. The study appeared in the journal Nature. (Read: 6 symptoms of liver disease you shouldn't ignore)
What is liver cancer?
It is a condition that can be caused by many factors including viral infections (hepatitis B and C), chronic alcoholism, certain food contaminants, genetic factors, cirrhosis of the liver. It is when the cells within the liver multiply unnaturally leading to formation of a mass or scar tissue. Scar tissue is a type of tissue that forms over a damaged area of the liver. It is the body's way of healing. Unfortunately this tissue leads to the improper functioning of the liver and can lead to cancer.
You may also like to read:
With inputs from IANS
For more articles on cancer, visit our cancer section. Follow us on Facebook and Twitter for all the latest updates! For daily free health tips, sign up for our newsletter. And to join discussions on health topics of your choice, visit our forum.