Agencies
... Read More
By clicking “Accept All Cookies”, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Cookie Policy.
Written By: Agencies | Published : January 31, 2017 9:14 AM IST
A new study finds that altering the shape of a protein can significantly reduce the progression of inflammatory bowel disease and colon cancer. According to researchers, modifying the shape of IRAK-M, a protein that controls inflammation, can significantly reduce the clinical progression of both diseases in pre-clinical animal models. The findings appeared in the eBioMedicine journal. "When we tested mice with the altered IRAK-M protein, they had less inflammation overall and remarkably less cancer," said Coy Allen from the Virginia-Maryland College of Veterinary Medicine. The next step, he said, will be to evaluate these findings in human patients through ongoing collaborations with Carilion Clinic and Duke University.
The altered protein causes the immune system to become supercharged, clearing out the bacteria before they can do any damage. There is an intimate link between uncontrolled inflammation in the gut associated with inflammatory bowel disease and the eventual development of colon cancer. From a scientist's perspective, that's what it's all about, and hopefully our findings provide a good avenue for development of future therapeutics to treat maladies such as inflammatory bowel disease and colon cancer, the authors concluded. When talking about colon cancer, there is no defined cause for its onset, experts suggest that in several cases the cause is genetic in nature (inheritance of mutated gene). Certain risk factors like inflammation in the intestine, high fat diet, older age, diabetes, smoking and obesity increase its risk. Symptoms include diarrhea, constipation with a feeling of heaviness in the rectum, discharge of blood from the rectum, abdominal pain, cramps and severe weight loss.(Read: Scientists identify rare form of hereditary colon cancer)
Source: ANI
Image source: Shutterstock
