Written By: Satata Karmakar | Updated : November 10, 2021 11:56 AM IST
Protein-Based COVID-19 Vaccine: This Game Changer Coronavirus Vaccine Can Be Stored For 7 Days At Room Temperature
Vaccines are the only tool to fight the deadly coronavirus which is wrecking havoc worldwide, and in the run to ward of the COVID virus, scientists have developed a new protein-based vaccine that is much easier to produce and does not need refrigeration. Yes, you heard that right, the research team at Boston Children's Hospital, US, noted that currently available Covid vaccines require cold storage and sophisticated manufacturing capacity, which makes it difficult to produce and distribute them widely, especially in less developed countries. However, according to the researchers, the newly designed protein-based vaccine, also described in the PNAS journal, could help fill global vaccination gaps and could be applied to vaccines against other diseases. The new vaccine candidate elicited strong immune responses against SARS-CoV-2, the virus that causes COVID-19, and its variants in mice, the researchers said.
Talking about the improved qualities of the newly designed protein-based COVID-19 vaccine, the researchers said that they were able to successfully freeze-dry the doses and later reconstituted without losing efficacy. Researchers further added it remained stable and potent for at least seven days at room temperature. The new experimental COVID-19 vaccine is completely protein-based, making it easy for many facilities to manufacture. The researchers also said that the new vaccine has two components: antibodies derived from alpacas, known as nanobodies, and the portion of the virus's spike protein that it uses to enter the human cells, they said.
Speaking to the media, one of the researchers, Pishesha said, "We could also attach the whole spike protein or other parts of the virus," said study first author Novalia Pishesha. "And we can change the vaccine for SARS-CoV-2 variants quickly and easily." According to the study results, the vaccine-elicited robust humoral immunity against SARS-CoV-2, stimulating high amounts of neutralising antibodies against the spike protein fragment. It also elicited strong cellular immunity, stimulating the T helper cells that rally other immune defences, the researchers said.
Because the vaccine is a protein, rather than a messenger RNA like the Pfizer/BioNTech and Moderna vaccines, it lends itself much more to large-scale manufacturing, they said. "We don't need a lot of the fancy technology and expertise that you need to make an mRNA vaccine," said Thibault Harmand, co-first author of the study. "Skilled workers are currently a bottleneck for production of the COVID vaccine, whereas biopharma has a lot of experience producing protein-based therapeutics at scale," Harmand explained.
The new technology could potentially enable production of the vaccine at many sites around the world, close to where it would be used, the researchers said. They have filed a patent on their technology, and hope to engage biotech or pharmaceutical companies to take their work into further testing and, eventually, a clinical trial.
(With inputs from Agencies)
