Certain blood thinner drugs that reduce the process of blood clotting used for treating irregular heart rate disorder may put patients with chronic kidney diseases (CKD) at a higher risk of bleeding researchers have found. The direct oral anticoagulants -- type of blood thinners -- are cleared by the kidneys to varying degrees and their elimination is slower in individuals with CKD. This may predispose these patients to drug accumulation and a greater risk of bleeding events the researchers said. Despite sparse evidence in safety and effectiveness of direct oral anticoagulants in CKD we saw that prescription of direct oral
