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One single enzyme triggers diabetes!

diabetesA single enzyme promotes the obesity-induced oxidative stress in the pancreatic cells that leads to pre-diabetes and diabetes, researchers have discovered. The drugs that can interfere with this enzyme can prevent or even reversing diabetes. The enzymatic action by 12-lipoxygenase (12-LO) is the last step in the production of certain small molecules that harm the cell. 'Our research is the first to show that 12-LO in the beta cell is the culprit in the development of pre-diabetes, following high fat diets,' said principal investigator Raghavendra Mirmira from Indiana University's school of medicine, Indianapolis. For the study, researchers genetically engineered mice that lacked the gene for 12-LO exclusively in their pancreas cells. (Read: Sample diet plan for diabetics)

Mice were either fed a low-fat or high-fat diet. Both the control mice and the knockout mice on the high fat diet developed obesity and insulin resistance. The investigators also examined the pancreatic beta cells of both knockout and control mice. Those from the knockout mice were intact and healthy while those from the control mice showed oxidative damage, demonstrating that 12-LO and the resulting hydroxyeicosatetraenoic acid (HETEs) caused the beta cell failure. (Read: 10 diet dos and don'ts for diabetics)

HETEs harm the mitochondria, which then fail to produce sufficient energy to enable the pancreatic cells to manufacture the necessary quantities of insulin. The fatty diet used in the study comprised mostly saturated (bad) fats. According to Mirmira, the unsaturated and mono-unsaturated fats are unlikely to have the same effects. The research was published online in the journal Molecular and Cellular Biology. (Read: 10 tips to prevent diabetes)

Here are some tips to live well with Type 2 Diabetes

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  • Eat regular meals. Have at least three meals at about the same time everyday. Eating every four to five hours can help control blood sugar. Always carry with you some type of carbohydrate food or drink that has 10 to 15 grams of carbohydrate which you can use in case of emergency (low glucose level).
  • Eat a variety of foods. Choose foods that fulfill your body's nutritional needs. Eat less fat, less sugar and less salt. Avoid fried foods. Baked, boiled or steamed foods are healthier to eat. Avoid red meat. Have low fat dairy products. Eat more high-fiber foods, like vegetables, fruit and whole grain breads and cereals.
  • Monitor your blood glucose two to four times every day with a blood glucose meter,if your doctor has advised you to. It is an electronic device for measuring the blood glucose at home. The blood glucose test is performed by pricking your finger with a small, sharp needle (lancet), putting a drop of blood on a chemically active disposable test strip and then placing the strip into a digital meter that displays your blood sugar level. Within a few seconds, the blood glucose level will be shown on the digital display. Read more about Tips to live well with Type 2 Diabetes

With inputs from IANS

Photo source: Getty images

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