Most people think that depletion of platelets due to dengue fever is a major cause of concern and could be a life-threatening condition. The general belief is that since platelets work in blood coagulation the lack of it or a dip in the numbers could lead to internal bleeding and if the problem persists it could lead to subsequent death. In general the normal blood platelet counts in humans range between 1.5 to 4 lakh. When affected by dengue fever platelet count falls. This is the most significant manifestation of dengue and people often panic seeing the low platelet count