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Written By: Editorial Team | Published : March 4, 2014 6:55 PM IST
Scientists have identified a gene thought to play a causal role in the development of Alzheimer's disease. The gene, identified by researchers including one from Simon Fraser University in Canada, affects accumulation of amyloid-beta, a protein believed to be one of the main causes of the damage that underpins this brain disease in humans. The gene encodes a protein that is important for intracellular transportation.
Each brain cell relies on an internal highway system that transports molecular signals needed for the development, communication, and survival of the cell. This system's impairment can disrupt amyloid-beta processing, causing its eventual accumulation. This contributes to the development of amyloid plaques, which are a key hallmark of Alzheimer's disease. 'Alzheimer's is a multifactorial disease where a build-up of subtle problems develop in the nervous system over a span of decades,' said Michael Silverman, an SFU biology associate professor who worked on the study with a team of Japanese scientists led by Dr Takashi Morihara at Osaka University.(Read: Exposure to pesticides linked to Alzheimer's disease)
'Alzheimer's, like many human disorders, has a genetic component, yet many environmental and lifestyle factors contribute to the disease as well,' said Silverman. 'In a sense, it is like looking for a needle in a complex genetic haystack,' he added. The gene discovery could open new avenues for the design of therapeutics and pave the way for early detection by helping healthcare professionals identify those who are predisposed to the disease, researchers said. 'One possibility is that a genetic test for a particular variant of this newly discovered gene, along with other variants of genes that contribute to Alzheimer's, will help to give a person their overall risk for the disease,' said Silverman.(Read: 'Alzheimer's is no more an old age condition')
'Lifestyle changes, such as improved diet, exercise, and an increase in cognitive stimulation may then help to slow the progression of Alzheimer's,' he said. The study was published in the Proceedings of the National Academy of Sciences.
What is Alzheimer's?
Alzheimer's disease is a degenerative mental disease that causes problems with memory, thinking and behaviour. It is the most common form of dementia and is commonly seen in the elderly. While the chances of developing the disease increase with age, it is now seen that younger people are also now being diagnosedwith the disease. (Read: Alzeimer's disease it's more common than you think)
With inputs from PTI
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