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Home / Health News / Memory stored in nerve cells key to wiping out pain

Memory stored in nerve cells key to wiping out pain

Researchers have found the key to how memories of pain are stored in the brain, especially in nerve cells (neurons), and how they can be erased to ease pain.

By: Admin   | | Updated: February 14, 2012 8:38 pm
Tags: Brain  Memory  Nerve cells  Neurons  

NeuronsResearchers have found the key to how memories of pain are stored in the brain, especially in nerve cells (neurons), and how they can be erased to ease pain. Also Read - Opioid addiction can cause permanent brain changes

The central nervous system is known to “remember” painful experiences, that they leave a memory trace of pain.  Also Read - Scientists compare human brain neurons with crabs to validate RNA sequencing



And when there is new sensory input, the pain memory trace in the brain magnifies the feeling so that even a gentle touch can be excruciating. Also Read - New study states drops in income can harm your brain

“Perhaps the best example of a pain memory trace is found with phantom limb pain,” suggests McGill University neuroscientist Terence Coderre.

“Patients may have a limb amputated because of gangrene, the patients continue to feel they are suffering from pain in the absent limb,” he said, according to a McGill statement. 

Recent work has shown that the protein kinase PKMzeta plays a crucial role in building and maintaining memory by strengthening the connections between neurons (nerve cells). 

Now Coderre and his colleagues have discovered that PKMzeta is also the key to understanding how the memory of pain is stored in the neurons. They were able to show that after painful stimulation, the level of PKMzeta increases persistently in the central nervous system (CNS).

Even more importantly, the researchers found that by blocking the activity of PKMzeta at the neuronal level reverses the hypersensitivity to pain that neurons develop after irritating the skin by applying capsaicin — the active ingredient in hot peppers. 

Source: IANS

Published : February 14, 2012 8:18 pm | Updated:February 14, 2012 8:38 pm
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