According to a study estrogen and other sex hormones could be responsible for the higher prevalence of migraine in women. We can observe significant differences in our experimental migraine model between males and females and are trying to understand the molecular correlates responsible for these differences explained Professor Antonio Ferrer-Montiel from the Universitas Miguel Hernandez Spain. Although this is a complex process we believe that modulation of the trigeminovascular system by sex hormones plays an important role that has not been properly addressed. Ferrer-Montiel and his team reviewed decades of literature on sex hormones migraine sensitivity and cells' responses to