Researchers led by Indian origin scientist Ravindra Uppaluri from Washington University School of Medicine in St Louis have found a way to predict the aggressiveness of oral tumours in people. The discovery would soon lead to an easily available diagnostic test that could guide treatment according to researchers. Working on mice the investigators found a consistent pattern of gene expression associated with tumour spreading in mice. Analysing genetic data from human oral cancer samples they also found this gene signature in people with aggressive metastatic tumours. 'We didn't automatically assume this mouse model would be relevant to human oral cancer'