A recent study has established that high dose intake of opioid is not effective in reducing pain. The researchers' team from Central Arkansas and Minneapolis VA Health Care Systems and three universities have suggested after studying available data that patients who got their opioid dosage increased were not helped by the higher dosage as compared to those who continued with earlier dosage. The Veterans Affairs study looked at prescribing data of more than 50000 VA patients taking opioids. The findings led the study authors to warn: Clinicians should exercise extreme caution when embarking on a path of increasing opioid doses