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Home / Health News / If this tiny liver protein is disrupted, it could lead to cardiovascular disease

If this tiny liver protein is disrupted, it could lead to cardiovascular disease

Here's how a protein secreted by your liver could potentially put you at the risk of cardiovascular diseases as well as fatty liver disease.

By: Agencies   | | Updated: June 12, 2016 7:41 pm
Tags: Cardiovascular diseases  health  
liver disease

Scientists have identified for the first time a tiny liver protein that when disrupted can lead to cardiovascular disease as well as fatty liver disease — a precursor to cancer. Here are 5 natural ways to keep fatty liver disease at bay. Also Read - Excessive sweating, earlobe crease and other signs of an impending heart attack

Also Read - World Heart Day 2020: Why India faces higher mortality from cardiovascular diseases?



Lipoproteins (VLDL) are crucial for healthy liver function. Normal VLDL secretion must be kept in a delicate balance as too little VLDL secretion causes fatty liver and, potentially, liver cancer. Lipoproteins are also known to increase cholesterol levels, a risk factor for plaque buildup in the arteries. Also Read - Arthritis drugs may reduce risk of developing heart disease

In a study, published recently in the Journal of Biological Chemistry, Shadab Siddiqi from University of Central Florida found a tiny protein — called a Small Valosin-Containing Protein Interacting Protein (SVIP) — that regulates how much VLDL is secreted into the blood. SVIP in the liver must be regulated properly to ensure optimum health, Siddiqi said. Read: Experts say there is an increase in the number of non-alcoholic fatty liver diseases.

He equates the operation of the tiny protein to a manually operated car. To run smoothly, the driver must synchronise the gas pedal and the clutch. If the two aren’t synchronised, the car doesn’t move easily; it has fits and starts and ultimately stalls, he said.

The study also suggests that high levels of myristic acid in the diet — through animal and dairy fats — keep SVIP from properly regulating the liver’s secretion of VLDL. These findings suggest that our diet modulates the complex molecular processes that have profound effects on our health and lifespan, Siddiqi explained.

The challenge will be in creating a therapy that does not impact the liver’s many other functions, he added. Read: 6 tests to check your liver function.

Source: IANS

Image Source: Shutterstock

Published : June 12, 2016 7:41 pm | Updated:June 12, 2016 7:41 pm
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