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Home / Health News / Flu-fighting enzyme may in the future make influenza a thing of the past!

Flu-fighting enzyme may in the future make influenza a thing of the past!

Researchers have found a new enzyme, known as cIAP2, which helps the lungs fight against infection by giving them the ability to decrease flu-inflicted tissue injury. Dr. Maya Saleh of the Department

By: Agencies   | | Published: January 17, 2014 9:58 am
Tags: Enzyme  Flu  In the news  

Typhoid feverResearchers have found a new enzyme, known as cIAP2, which helps the lungs fight against infection by giving them the ability to decrease flu-inflicted tissue injury. Dr. Maya Saleh of the Department of Medicine of the McGill University Health Centre said that the new discovery offers exciting new avenues for controlling influenza, since until now attempts to target the virus itself have proven challenging, especially in the face of emerging new strains of the virus. Also Read - Vitamin D supplements don't help ward off colds and flus

Saleh asserted that the results from the study now suggest that one effective way of countering influenza infections may instead be offered by enhancing the body’s resistance to the virus. Like many other battles, fighting the flu is a combination of both control and defence. (Read: A drug that can destroy the influenza virus, now on the horizon)
Also Read - 25 dead so far in S Korea’s attempt to avoid ‘twindemic’: But flu shot programme to continue



On the one hand, on the control end of the process, our immune system comes into play to prevent the virus from replicating inside our cells, and attacking with increasing strength. At the same time, on the defensive side, our bodies need to actively resist the destruction and harmful cell death that is caused by the virus. Also Read - Ganesh Chaturthi 2020: 4 reasons an eco-friendly Ganesha is good for you

By investigating the role played by cIAP2 in mice with the H1N1 influenza A virus, what Saleh and her team discovered was that the enzyme is necessary to control the nature of cell death during influenza infection.

They found that cIAP2, which functions by modifying and activating survival factors in the cell, steers the body away from an inflammatory and auto-destructive process known as necrotic death. The enzyme is, in effect, a gatekeeper of cell death. (Read: Universal vaccine against influenza possible?)

In its absence, the same factors that depend on cIAP2 to keep the cell alive, reveal a destructive side and induce a harmful form of cell death. cIAP2 therefore not only protects the infected cells from dying in such a manner, but also protects uninfected neighboring cells in the same tissue.

By doing so, this enzyme increases the resistance of the lung to influenza infection and associated pathology. The study is published in the journal Cell Host and Microbe. (Read: Now a drug that can prevent influenza deaths)

Source: ANI

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Published : January 17, 2014 9:58 am
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