Explained: This is how coronavirus interacts with proteins in human cells

According to the researchers, including those from Broad Institute in the US, one of the most urgent tasks is to understand all the molecular interactions between the virus and the cells it infects.

By: Satata Karmakar | | Published: December 27, 2020 9:53 am

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Scientists have charted the first atlas showing how the genetic material of the novel coronavirus interacts with the proteins in human cells, an advance that may provide a starting point for the development of new treatments against COVID-19. Also Read - You are at higher risk to catch Coronavirus in closed spaces. Here’s how

According to the researchers, including those from Broad Institute in the US, one of the most urgent tasks is to understand all the molecular interactions between the virus and the cells it infects. Also Read - Patients with inactive cancer at high risk of severe COVID-19 infection; Study suggests

They explained that a detailed understanding of these interactions will help identify the processes in host cells that favour the multiplication of the virus, and the ones which activate the host immune system. Also Read - Alert! Coronavirus spike proteins may evolve to evade immune responses

The SARS-CoV-2 virus uses the host to replicate

While the SARS-CoV-2 virus uses host proteins to replicate, the scientists said until now, there has been no detailed understanding of all the proteins occurring in human cells that interact with the viral genetic material — its RNA.

In the current research, published in the journal Nature Microbiology, the scientists created the first global atlas of direct interactions between the SARS-CoV-2 RNA and the proteins present in human cells.

Based on the findings, the researchers also identified important regulators of viral replication.

The scientists infected human cells with the novel coronavirus, purified the viral RNA, and identified the proteins bound to it.

“In this particular case, we were able to perform quantitative measurements to identify the strongest specific binding partners,” said study co-author Mathias Munschauer from the Helmholtz Institute for RNA-based Infection Research (HIRI) in Germany.

The atlas of RNA-protein interactions offers unique insights into SARS-CoV-2 infections

The scientists said the atlas of RNA-protein interactions offers unique insights into SARS-CoV-2 infections, enabling the systematic breakdown of factors influencing the replication of the virus, and host defense strategies — a crucial prerequisite for the development of new therapeutics.

From the results, the scientists identified 18 host proteins that play an important role during SARS-CoV-2 infection and found 20 small molecules that may inhibit these proteins.

They believe the two proteins CNBP and LARP1 are particularly interesting.

The researchers also identified target sites in these proteins that could be used to inhibit the replication of the virus.

According to Munschauer, the characterization of LARP1 as an antiviral factor is a major finding.

“The way LARP1 binds to viral RNA is very interesting because it is similar to the way LARP1 regulates certain cellular messenger RNAs that we already know. This in turn provides insights into possible mechanisms of action,” he added.

According to the scientists, three out of four small molecules they tested inhibited viral replication in different human cell types — findings that may open up new ways to treat COVID-19.

(With inputs from Agencies)

Published : December 27, 2020 9:53 am

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