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Home / Health News / Excessive noise can damage your unborn baby’s brain

Excessive noise can damage your unborn baby’s brain

Here's another reason to stay away from too much noise pollution.

By: Agencies   | | Updated: April 20, 2016 12:26 am
Tags: Brain damage  Embryo  Noise  Noise pollution  
embryo silhouette in woman hand

Too much noise can not only damage your ears but it can also adversely affect our brain development, finds a recent study that was published in an online journal known as eLife. These are the 7 everyday things that are silently killing your brain. Also Read - Sedative drugs, curb on family visits may increase risk of acute brain dysfunction in Covid-19 ICU patients

Also Read - High blood pressure in midlife ups your risk of brain damage in later life



Using cutting-edge imaging technology, University of California, Irvine biologists have determined that uncontrolled fluctuations, known as “noise,” in the concentration of the vitamin A derivative Retinoic acid (RA) can lead to disruptions in brain organization during development. Also Read - COVID-19 infection may cause irreversible brain damage

Identifying how a cell responds to a signal made by another cell, despite the level of noise present, may improve our understanding of developmental disorders.

During development, RA is an important secreted molecule that aids in the proper organization of the brain. The cellular response to RA depends upon its concentration, which is determined by its production, movement through tissue and interactions with many proteins within the cell. During normal development, cells can filter the “noise” in RA levels and establish appropriate brain organization.

Researcher Thomas F. Schilling and lead author Julian Sosnik wanted to measure the fluctuations in RA and determine how cells respond to the proper amount despite the presence of constant noise.

The team used fluorescence lifetime imaging to exploit the auto-fluorescent nature of RA and measure its distribution across the developing zebrafish embryo. They found that RA forms a gradient in the embryo, with a lower concentration at the head. They also observed that a large amount of noise exists within the RA gradient.

They identified one protein within developing cells that interacts with RA to help reduce the noise. When this protein was altered, cells could no longer control the level of noise within the RA gradient, which led to disruptions in brain organization.

With this, the researchers concluded that noise reduction within cells is critical for the proper response to the RA gradient and normal organization of the brain. Read: Your decisions depend on the background noise in your brain.

Source: ANI

Image Source: Shutterstock

Published : April 16, 2016 3:15 pm | Updated:April 20, 2016 12:26 am
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