Discovered – how exactly obesity leads to type 2 diabetes, cancer

A researcher has said that new findings about the biological links between obesity, insulin resistance and type 2 diabetes may could also help shed light on the connection between obesity and cancer.

By: Editorial Team | | Updated: June 6, 2014 6:42 pm

A researcher has said that new findings about the biological links between obesity, insulin resistance and type 2 diabetes may could also help shed light on the connection between obesity and cancer. Also Read - Ganesh Chaturthi 2020: 4 reasons an eco-friendly Ganesha is good for you

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In the study, UT Dallas’ Dr. Jung-whan (Jay) Kim and colleagues at the University of California, San Diego found that a protein called HIF-1 alpha plays a key role in the development of insulin resistance and type 2 diabetes in obese mice. The researchers genetically engineered mice to lack the HIF-1 alpha protein within the animals’ fat cells, or adipocytes. The animals still made HIF-1 alpha in other types of cells and tissues in their bodies. Also Read - Weight loss diet: How to eat healthy in a restaurant when you want to lose weight

Although the mice became obese when fed a high-fat diet, they did not develop insulin resistance and diabetes to near the extent that genetically normal, obese mice did. Kim, a co-lead author of the study who conducted the research while a postdoctoral researcher at UC San Diego and the Salk Institute for Biological Studies, said that there is clearly a greater chance among the obese human population to develop insulin resistance and diabetes. (Read: Expert tips to deal with type 2 diabetes)

Kim said the findings about HIF-1, which stands for hypoxia inducible factor-1, are significant not only for their possible application to fighting insulin resistance and diabetes, but also cancer. Here’s why: To study the effect HIF-1 alpha might have on the development of insulin resistance and diabetes, Kim and his colleagues used genetic engineering techniques to completely remove, or “knock out” HIF-1 alpha from adipose tissue in obese mice. (Read: Natural ‘cure’ for type 2 diabetes soon?)

He said tumor cells grow really fast, but the blood vessels that feed them oxygen cannot grow fast enough, so tumor cells become hypoxic, adding that the tumor cells have to develop some sort of mechanism to survive under hypoxic stress, and that’s HIF-1 alpha. Kim said that if one can inhibit HIF-1 alpha in a tumor cell, one can kill the cell, and that’s why pharmaceutical companies are interested in HIF-1 inhibitors. (Read: Gene mutations can reduce risk of Type-2 diabetes)

The study has been published online in the journal Cell.

What is type 2 diabetes?

Type 2 diabetes is the more commonly found form of diabetes. It is an endocrine disorder where the pancreas may be producing insulin but your body may not be able to use it properly. This cause a rise in blood sugar levels. Due to the modern lifestyle where people are mostly sedentary, eat processed foods and lead a stressful life, type 2 diabetes is fast becoming the most common disease around the world with India leading the pack. (Read: Tips to live well with Type 2 Diabetes)

With inputs from ANI

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Published : June 6, 2014 4:18 pm | Updated:June 6, 2014 6:42 pm

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