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Scientists studying the evolution of HIV in North America have found evidence that the virus is slowly adapting over time to its human hosts. However, this change is so gradual that it is unlikely to have an impact on vaccine design, researchers said. 'Much research has focused on how HIV adapts to antiviral drugs we wanted to investigate how HIV adapts to us, its human hosts, over time,' said lead author Zabrina Brumme, an assistant professor in the Faculty of Health Sciences at Simon Fraser University.
'HIV adapts to the immune response in reproducible ways. In theory, this could be bad news for host immunity and vaccines if such mutations were to spread in the population,' said Brumme. 'Just like transmitted drug resistance can compromise treatment success, transmitted immune escape mutations could erode our ability to naturally fight HIV,' said Brumme. Researchers characterised the human immunodeficiency virus (HIV) sequences from patients dating from 1979, the beginning of the North American HIV epidemic, to the modern day. (Read: 12 HIV/AIDS symptoms that you need to watch out for)
The team reconstructed the epidemic's ancestral HIV sequence and from there, assessed the spread of immune escape mutations in the population. 'Overall, our results show that the virus is adapting very slowly in North America. In parts of the world harder hit by HIV though, rates of adaptation could be higher,' said Brumme. 'We already have the tools to curb HIV in the form of treatment and we continue to advance towards a vaccine and a cure. Together, we can stop HIV/AIDS before the virus subverts host immunity through population-level adaptation,' Brumme added. (Read: Coming soon an effective HIV vaccine?)
The study was published in the journal PLOS Genetics.
What is HIV/AIDS?
HIV/AIDS is a disease that affects the human immune system. AIDS is the final stage of Human Immunodeficiency Virus (HIV) infection. If an HIV positive person is left untreated, his/her condition deteriorates into full-blown AIDS where the immune system stops working. Thus the immune system is unable to protect the person from diseases or infections. The virus can be transmitted from an HIV positive person through the exchange of body fluids. This can happen through sexual contact, blood transfusion, needles or from a mother to child during pregnancy. Though there is no cure yet, antiretroviral treatment has proven to be very effective. (Read: HIV/AIDS Causes, Symptoms, Tests, Treatment & More)
With inputs from PTI
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