Common diabetes drug can provide relief from nicotine withdrawal symptoms

Smokers trying to quit face potent side effects from nicotine withdrawal, including cravings, increased appetite, restlessness, anxiety, irritability, and depression. But a diabetes drug may offer relief.

By: ANI | | Published: November 5, 2019 9:04 pm

The diabetes drug, pioglitazone, targets a specific form of the peroxisome proliferator-activated receptors in the nucleus. © Shutterstock

A new research reveals that commonly used drugs to treat type II diabetes mitigate the characteristic signs of nicotine withdrawal in rats and mice. The finding may offer an important new strategy in the battle to quit smoking. The results of the study were published in the Journal of Neuroscience 2019.

Domi et al. demonstrated that direct injections of pioglitazone into the hippocampi of male mice reduced the signs of physical nicotine withdrawal, including paw tremors, chattering, and head shakes. Injecting pioglitazone into the amygdala of male mice ameliorated signs of anxiety associated with nicotine withdrawal.

Nicotine abusers face a 30 per cent higher risk of developing Type II diabetes. The researchers suggest pioglitazone may help diabetic smokers quit by lessening the physical and emotional withdrawal symptoms while reducing insulin resistance.

Published : November 5, 2019 9:04 pm

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