Switch to हिंदी

Health, Fitness, Beauty & Diet | Pregnancy & Parenting | Diseases & Home Remedies | TheHealthSite.com

हिंदी
  • Health A-Z
  • Home Remedies
  • Diseases
    • Type 1 Diabetes
    • Type 2 Diabetes
    • Cancer
    • Heart Attack
    • Pneumonia
    • Diseases A-Z
  • Diet & Fitness
    • Weight Management
    • Exercise & Body Building
    • Diet & Recipes
    • Yoga
  • Coronavirus
  • News
  • Pregnancy
    • Conceiving
    • Infertility
    • Labour & Delivery
    • Pregnancy week-by-week
    • Breastfeeding
    • Baby Names
  • Beauty
    • Skin
    • Hair
    • Grooming
  • Photos
  • Videos
Home / Health News / Combination of neurologic and BP drugs may help reduce breast tumour development

Combination of neurologic and BP drugs may help reduce breast tumour development

Adding a medication used to treat epilepsy, bipolar disorder and migraines to a blood pressure medicine was found to reverse some aspects of breast cancer in a lab test.

By: IANS   | | Updated: January 2, 2020 8:35 am
Tags: Blood Pressure  Breast cancer drug  Breast Tumours  
breast cancer
Smoking, alcohol intake, obesity and exposure to light late at night increase your risk of breast cancer © Shutterstock

Researchers have found that combining neurologic and blood pressure drugs may reduce breast tumour development. Also Read - Cannabis therapy may reduce blood pressure in older adults

According to the study, published in the journal Scientific Reports, adding a medication used to treat epilepsy, bipolar disorder and migraines to a blood pressure medicine reversed some aspects of breast cancer in the offspring of mice at high risk of the disease because of the high fat diet fed to their mothers during pregnancy. Also Read - Commonly used blood pressure medications safe for COVID-19 patients



“We believe that our research is the first to show that we can reverse some aspects of increased breast cancer risk found in offspring of mouse mothers fed a high fat diet during pregnancy,” said study researcher Leena A Hilakivi-Clarke from the Georgetown University in the US. Also Read - Hypertension: 7 Common myths about high blood pressure debunked

“This finding may have important implications in people because exposures in the womb to certain chemicals, or a mother’s high fat diet, or being obese, can subsequently increase a daughter’s breast cancer risk,” Hilakivi-Clarke.

According to the researchers, the key drug in the study regimen was valproic acid which, among several targets, inhibits histone deacetylase (HDAC), an important epigenetic silencer of genes.

In contrast to mutations that permanently disrupt the normal functions of genes, epigenetic modifications are reversible.

Valproic acid was combined with the blood pressure medication hydralazine that inhibits another critical epigenetic regulator, DNA methyltransferase (DNMT).

Early treatment studies in people have shown that these two drugs can work in tandem to disrupt tumour growth.

These research findings demonstrate how impactful an epigenetic methyl group addition or subtraction from DNA can be.

Compounds that reduce methylation of tumour suppressor genes that are excessively methylated (hypermethylated) can be beneficial.

However, these drugs can have the opposite effect if tumour suppressor genes are not hypermethylated; they may remove methyl groups from cancer-causing genes, making these genes more active and potentially leading to more aggressive cancers.

The other key aspect of this finding involves the potential impact of diet on cancer risk. Many fruits and vegetables have compounds (such as flavones) that chemically react in the same ways as the HDAC- and DNMT-inhibiting drugs in this study.

Some compounds in these foods, especially folic acid, have opposite effects.

This research suggests that exposure to a high fat diet or endocrine disrupting chemicals in the womb might be reversed by the consumption of foods high in DNMT and HDAC inhibitors, while those who have not had such exposures might also gain a cancer protective benefit from consuming foods high in folic acid.

The scientists noted, however, that their findings, particularly as they relate to diet, need to be studied in people.

“Our next step will be to try to identify biomarkers in humans that indicate an exposure in the womb to diets or endocrine disrupting chemicals that could increase breast cancer risk later in life,” said Hilakivi-Clarke.

Published : January 2, 2020 8:28 am | Updated:January 2, 2020 8:35 am
Read Disclaimer

New drug reduces disease progression in knee osteoarthritis

New drug reduces disease progression in knee osteoarthritis

Drinking whole milk may lower your kid’s risk of becoming overweight

Drinking whole milk may lower your kid’s risk of becoming overweight

Please Wait. Article Loading ....

Coronavirus Updates

Coronavirus Updates

Stay Informed, Be Safe

  • Woman Dies Two Days After Receiving COVID-19 Vaccine Jab, Cremated Without Post-Mortem In Hyderabad
  • Delhi COVID-19 situation critical: Kejriwal seeks centre’s help as surge continue amid restrictions
  • Lockdown Imposed In Delhi From Tonight Amid COVID-19 Surge: Here's What’s Allowed, What’s Shut
  • Rajasthan Government Imposes 15-Day Lockdown Due To Covid-19 Surge
  • Covid-19 patients with poor lifestyle habits are at a higher risk of death

Health Calculators

BMI Calculator
bmi Calculator
Ideal Body Weight
ideal body weight
Daily Calorie Intake
Daily calorie intake
Calories Burned
calories burned

Related Stories

Common BP medication may up your risk of skin cancer; Know all about it

Common BP medication may up your risk of skin cancer; Know all about it

Tea, Garlic and Other Foods That Have BP-lowering Properties

Tea, Garlic and Other Foods That Have BP-lowering Properties

Beta Blockers May Put HIV Patients at Higher Risk of Heart Disease, Stroke and Heart Failure

Beta Blockers May Put HIV Patients at Higher Risk of Heart Disease, Stroke and Heart Failure

Fasting before starting DASH diet can give you better results

Fasting before starting DASH diet can give you better results

Is high blood pressure the reason why you are experiencing headaches?

Is high blood pressure the reason why you are experiencing headaches?

Health News in Hindi

कोरोना वैक्सीन लगाने से नहीं होता संक्रमण, टीकाकरण के बाद रिपोर्ट पॉजिटिव आने के पीछे हो सकता है ये कारण

Home Treatments for Shortness of Breath: कोरोना में सांस की समस्‍या को दूर करेंगे ये 5 होम ट्रीटमेंट, नहीं पड़ेगी भर्ती होने की जरूरत

कोरोना से लड़ेगी 21 पौधों से तैयार की गई ये आयुर्वेदिक दवा, कई कोविड मरीजों के ठीक होने का दावा

कोरोना टाइम में प्रेग्नेंट लेडी खुद का ध्यान कैसे रखें, एक्‍सपर्ट की सलाह जानने के लिए देखें वीडियो

Corona in UP: उत्‍तर प्रदेश में कोरोना की बुरी स्थित, एक ही पुलिस स्‍टेशन के 7 पुलिसकर्मी कोरोना पॉजिटिव

Read All

Recent Posts

  • World Liver Day 2021: Over-The-Counter Medicines For Liver Can Damage The Organ Permanently, Warn Doctors
  • Woman Dies Two Days After Receiving COVID-19 Vaccine Jab, Cremated Without Post-Mortem In Hyderabad
  • Expert Skin Care Tips To Fight Summer Dryness
  • Think before you consume energy drinks! They can lead to heart failure
  • World Liver Day 2021: Precautions For Liver Disease Patients In Times Of COVID-19 Infection

About The health Site

TheHealthSite.com is India's largest health site with more than 40 lakh unique visitors per month. We focus on fitness, beauty, health, pregnancy and more.

Most popular health and wellness website in India in 2012 at the Website of the year awards.

health@corp.india.com
+91 – 22 – 6697 1234
Landline Phone number 91 – 22 – 2490 0302.

ZEE ENTERTAINMENT ENTERPRISES LTD, 18th floor, A-Wing, Marathon Futurex, N. M. Joshi Marg, Lower Parel, Mumbai, Maharashtra 400013.

Useful Links

  • Weight Loss
  • Keto Diet Tips
  • Skin Care Tips
  • Intermittent Fasting
  • Apple Cider Vinegar
  • Ashwagandha
  • Cancer
  • Pneumonia
  • Diarrhoea
  • Dengue
  • Typhoid
  • Tuberculosis
  • Chickenpox
  • Chikungunya
  • Depression
  • Hepatitis
  • Diabetes
  • Type 2 diabetes
  • Arthritis
  • Swine Flu
  • Baby Names
  • Cough and cold
  • Heart Attack
  • Breast Cancer
  • Ebola Virus
  • Dengue
  • Malaria
  • International Yoga Day
  • Hypotension
  • Heart Failure
  • Asthma
  • Brain Tumour
  • Celebrity Fitness
  • Goitre
  • HIV/AIDS

We respect your privacy

  • Disclaimer
  • Privacy Policy
  • Contact Us
  • Author Profiles

Copyright © 2021 Zee Entertainment Enterprises Limited. All rights reserved.