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Written By: Agencies | Published : June 26, 2016 2:56 PM IST
Diabetes: Men are far more likely to develop type 2 diabetes as compared to women [4]. A study published in the journal Diabetologia revealed that biologically, men are far more susceptible to develop diabetes after studying a little more than 95,000 men and women living with this lifestyle disease.
Children born with low birth weight due to genetic factors are at increased risk of developing Type 2 diabetes, finds a new study. The findings showed that the low birth weight was actually causing excess risk in Type 2 diabetes. A genetically lowered birth weight was associated with increased susceptibility to Type 2 diabetes, said Tiange Wang from Tulane University in the US. Low birth can cause restricted intrauterine growth (foetal growth) -- a condition in which an unborn baby is smaller than it should be because it is not growing at a normal rate inside the womb.
Further, this restricted foetal growth also represents a risk factor for the low birth weight and in turn causing the Type 2 diabetes. Risk factors for restricted intrauterine growth include malnutrition, anaemia, infections and placental insufficiency. Our findings support a potential causal relation between birth weight and risk of Type 2 diabetes, providing novel evidence to support the role of intrauterine exposures in the pathogenesis of type 2 diabetes, Wang added. Evidence from both population and experimental studies has suggested that restricted early life development has long-term structural and functional influence on individuals' predisposition to an increased risk of metabolic diseases such as Type 2 diabetes, said the paper published in the journal Diabetologia. Stress during pregnancy can lead to low birth weight in babies.
The study included 3627 Type 2 diabetes cases and 12,974 controls. The team created a genetic risk score (GRS) based on five low birth weight-related genetic variations known as single nucleotide polymorphisms (SNPs). The analysis showed that for each one point increase in GRS (with the score ranging from 1-10), the risk of developing Type 2 diabetes increased by six per cent.
Source: ANI
Image source: Getty Images
