Certain types of mouth bacteria may increase risk of lung cancer in non-smokers

The type and abundance of bacteria found in the mouth may be linked to lung cancer risk in non-smokers. Read on to know more.

By: Jahnavi Sarma | | Updated: December 17, 2020 10:17 am

Mouth bacteria may provoke chronic inflammation, boost cell proliferation and inhibit cell death, prompt DNA changes, and switch on cancer genes and their blood supply.

Lung cancer kills millions of people around the world. But smoking is not the only cause of this disease as many non-smokers too fall prey to this kind of cancer. Around one in four cases of lung cancer occurs in non-smokers and known risk factors, such as second-hand tobacco smoke, background radon exposure, air pollution, and family history of lung cancer don’t fully explain these figures. Experts have been intrigued by this for a long time now and have tried to figure out why this happens. Some are susceptible to it due to genes, but many have no known genetic trigger, nor do they smoke. Now a new study published online in the journal Thorax says that the type and abundance of bacteria found in the mouth may be linked to lung cancer risk in non-smokers. Also Read - Lung cancer cases up five-fold in non-smokers, air pollution is the major culprit

Mouth bacteria linked to other cancers too

According to researchers, this heightened risk may be due to the presence of a fewer species and high numbers of a particular types of bacteria in the mouth. The type and volume of bacteria (microbiome), found in the mouth has been associated with a heightened risk of various cancers including those of the gullet, head and neck, and pancreas cancer. And the researchers wanted to find out if this association might also hold for lung cancer, given that the mouth is the entry point for bacteria to the lungs. Also Read - Unexplained back pain could be a sign of lung cancer

For the purpose of the study, they drew on participants in The Shanghai Women’s Health Study and the Shanghai Men’s Health Study, all of whom were lifelong non-smokers, and whose health was monitored every 2-3 years after entry to the study between 1996 and 2006. At enrolment, participants rinsed out their mouths to provide a profile of the resident bacteria, and information was obtained on lifestyle, diet, medical history and other environmental and workplace factors that might influence their disease risk. In all, 90 of the women and 24 of the men developed lung cancer within around 7 years, on average. These cases were matched with 114 non-smokers of the same age and sex, who also provided a mouth rinse sample. This comparison group didn’t have lung cancer, but they had similar levels of education and family histories of lung cancer. Also Read - Cancer cases in India will increase by 12% in five years: ICMR

Lactobacillales increases risk of lung cancer

Comparison of both sets of rinse samples showed that the microbiome differed between the two groups. A wider range of bacterial species was associated with a lower risk of developing lung cancer. And a larger volume of particular types of species was also associated with lung cancer risk. A larger volume of Bacteroidetes and Spirochaetes species was associated with lower risk while a larger volume of Firmicutes species was associated with heightened risk. Specifically, within the Spirochaetes species, a greater abundance of Spirochaetia was associated with lower risk; and within the Firmicutes species, a larger volume of organisms from the Lactobacillales order of microbes was associated with a heightened risk.

The associations remained when the analysis was restricted to those participants who had not taken any antibiotics in the 7 days before sample collection and after excluding those diagnosed with lung cancer within 2 years of sample provision. This is an observational study, and therefore can’t establish cause. And the researchers acknowledge several limitations. However, this study provides evidence that variation in the oral microbiome plays a role in lung cancer risk.

Some mouth bacteria may trigger DNA change

Mouth bacteria may provoke chronic inflammation, boost cell proliferation and inhibit cell death, prompt DNA changes, and switch on cancer genes and their blood supply, which would help to explain the findings. But further studies are needed to answer questions like how stable is the human oral microbiome over time? Second, if the human oral microbiome varies over time, what determines that variability? Third, how does the ambient environment such as exposure to air pollutants, affect the oral (and lung) microbiome?

(With inputs from Agencies)

Published : December 16, 2020 9:48 pm | Updated:December 17, 2020 10:17 am

Read Disclaimer