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Can laughing gas treat severe depression?

Can laughing gas treat severe depression?

Written by Agencies |Published : December 10, 2014 4:43 PM IST

Washington, 10 December 2014: According to a study published online in the journal Biological Psychiatry, laughing gas or nitrous oxide could be used as a treatment for severe depression in patients whose symptoms don't respond to normal therapies.

The study conducted by researchers at Washington University School of Medicine in St. Louis, was carried out on 20 patients, who had treatment-resistant clinical depression. It was found that two-thirds experienced an improvement in symptoms after receiving nitrous oxide. In comparison, one-third of the same patients reported improved symptoms after treatment with a placebo. The patients were evaluated on the day of and day after each treatment. The researchers said that their findings need to be replicated, but think that this was a good starting point, and believe that the therapy with nitrous oxide eventually could help many people with depression. (Read: Beat stress, fatigue and depression with laughter yoga)

As part of the study, patients received two treatments, but neither the subjects nor the researchers knew the order in which those treatments were given. In one session, patients were given a gas mixture that was half oxygen and half nitrous oxide the same mixture dentists give to patients undergoing dental procedures. In a second session, the patients received a placebo mixture of oxygen and nitrogen, the two main gases in the air we breathe. (Read: 5 health conditions that can lead to depression)

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The study subjects were surveyed about the severity of their symptoms, such as sadness, feelings of guilt, suicidal thoughts, anxiety and insomnia. One day after nitrous oxide treatment, seven patients reported mild improvement in their symptoms, while another seven reported significant improvement. Three patients reported that their symptoms had disappeared almost completely. No patients said their symptoms worsened after treatment with nitrous oxide.

Meanwhile, after receiving the placebo, one patient reported worse symptoms the next day, five reported mild improvements, and two reported that they felt significantly better. Co-investigator Charles R. Conway, MD, said that when the patients received nitrous oxide, many of them reported a rapid and significant improvement. The researchers said more studies were needed to learn whether nitrous oxide had the same benefits in other patients with depression. They also plan to test various concentrations of laughing gas to see how each influences symptoms of depression. (Read: 5 facts you didn t know about depression)

Source: ANI

Photo source: Getty images


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