Binge drinking causes insulin resistance which spurs a greater risk of Type 2 diabetes according to the results of an animal study. Insulin resistance (IR) arises when cells fail to respond to the normal actions of the hormone insulin. It delivers sugar to cells to provide them with energy. Researchers from the Diabetes Obesity and Metabolism Institute at the Icahn School of Medicine at Mount Sinai discovered that alcohol disrupts insulin-receptor signalling by causing inflammation in the hypothalamus area of the brain. This part links the nervous system to the endocrine system via the pituitary gland the journal Science Translational Medicine reports.