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Home / Health News / Ancient genetic mechanism’s discovery to aid treatment, finds Study

Ancient genetic mechanism’s discovery to aid treatment, finds Study

Researchers have found new evidence of advanced DNA regulation in an ancient marine organism that shows crucial mechanisms turning genes on and off may have originated much earlier than thought, a discovery that points to a better understanding of genetic processes and disease treatment.

By: Agencies   | | Updated: November 25, 2018 8:10 pm
Tags: DNA  Genes  Genome  
dna
Ancient genetic mechanism's discovery to aid treatment. © Shutterstock

Researchers have found new evidence of advanced DNA regulation in an ancient marine organism that shows crucial mechanisms turning genes on and off may have originated much earlier than thought, a discovery that points to a better understanding of genetic processes and disease treatment. Also Read - Genome sequencing of sewage water can help discover new coronavirus variants: US scientists

The study, co-led by Australian researchers, analysed the DNA of “Amphioxus” and uncovered the “tricks” used to control gene expression, which may have originated much earlier than thought, Xinhua news agency quoted a statement by Garvan Institute of Medical Research in Australia. Also Read - Genome sequencing for all international patients if tested Covid-19 positive: Why it is needed?



The translucent fish-like organism lay “right at the vertebrate-invertebrate boundary” and was “perfectly positioned to help us understand how our genomes made the leap from invertebrate to vertebrate”, said lead author Ozren Bogdanovic from the institute. Also Read - Junk DNA' affects risk of inherited cancer: Study

“With Amphioxus, we have one of the closest living invertebrate relatives to humans which is almost a vertebrate but not quite,” he added.

The ancient organism helped offer evidence of regions that are used to regulate gene expression, for the first time, in an invertebrate specie, he noted, in the paper published in the journal Nature.

“It tells us that this mechanism of regulation might have appeared millions of years earlier,” he said. “And this tells us a lot about how DNA regulation evolved, but also helps us understand more about how it works in more complex organisms, like ourselves.”

The next step in the study is to continue investigating the link between vertebrates and invertebrates, to gain a better understanding of DNA regulation, said Bogdanovic.

“This will allow us to deepen our understanding of how DNA regulation works, and especially how it goes wrong in diseases. Understanding these processes has the potential to help us better understand and ultimately treat diseases,” he said.

Published : November 25, 2018 4:57 pm | Updated:November 25, 2018 8:10 pm
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