A new therapy may be effective in slowing down Alzheimer's

According to a recent study, combination therapy may hold the key to slowing down Alzheimer's disease

By: Agencies | | Published: June 26, 2016 10:26 am

Studies have found that feeling socially isolated especially during old age, can put you at the increased risk of dementia [1]. The risk of Alzheimer's disease is more than double in lonely people as compared to those who are not lonely. Researchers say that loneliness is linked to a decline in one's cognitive functioning.

According to a recent study, combination therapy may hold the key to slowing down Alzheimer’s disease. Resveratrol is a naturally occurring polyphenolic phytochemical produced in several plants, especially grapes skin and seeds. One epidemiological study reported a positive association between moderate red wine consumption and a low incidence of cardiovascular disease, known as the French Paradox. The neuroprotective effects of resveratrol for the treatment of Alzheimer’s disease (AD) have been investigated in various in vitro and in vivo models of AD. Despite the high bioactivity of resveratrol in AD, there is poor bioavailability of resveratrol, that is, the concentrations required producing favourable biological effects in the brain and neuronal cells are insufficient to demonstrate efficacy in humans. These tips can help prevent onset of Alzheimer’s. Also Read - Traumatic brain injury can increase risk of Alzheimer's disease: Tips to avoid head injuries

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Therefore, successful clinical application of resveratrol as a single ‘take home’ oral therapy alone presents a major challenge for the treatment of AD. Researchers proposed a novel combination therapy consisting of an agent for chelating redox-active metals and/or an antioxidant to reduce damage caused by residual oxygen free radicals, in addition to resveratrol, a modulator of AMPK and sirtuin pathways (nuclear transcription). The addition of resveratrol may have the capacity to increase activity of the NAD+- dependant deacetylases such as sirtuin family enzymes (e.g. SIRT1) and promote improved DNA repair by enhancing PARP enzyme activity through increased production of their essential substrate NAD+, and thus improve cell viability and longevity. A synergistic combination of a selected antioxidant substances, Fe2+ chelating agents and resveratrol may be expected to provide a more clinically successful treatment. Also Read - World Alzheimer's Day 2020: Misfolded proteins in the gut may be the culprit

The study is published in Current Topics in Medicinal Chemistry.

Source: ANI

Image source: Getty Images

Published : June 26, 2016 10:26 am

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