A new drug without side effects to overcome depression

A drug that could ease out depression without any side-effects has been discovered by researchers in a clinical trial conducted by the National Institute of Health (NIH). The experimental drug AZD6765 eased hard-to-treat depression within hours, minus side-effects.

Prescription anti-depressants, working through the brain's serotonin system, take weeks to work, which might prompt severely depressed to commit suicide. Ketamine also works in hours, but its usefulness is limited by its potential for side-effects, including hallucinations. It is being studied mostly for clues to how it works.

'Our findings serve as a proof of concept that we can tap into an important component of the glutamate pathway to develop a new generation of safe, rapid-acting practical treatments for depression,' said Carlos Zarate, of the NIH's National Institute of Mental Health, which conducted the research, the journal Biological Psychiatry reported.

AZD6765, like ketamine, works by blocking glutamate binding to a protein on the surface of neurons, called the NMDA receptor. It is a less powerful blocker of the NMDA receptor, which may be a reason why it is better tolerated than ketamine, according to an NIH statement. About 32 percent of treatment-resistant depressed patients infused with ASD6765 showed a clinically meaningful response at 80 minutes after infusion that lasted for about half an hour - with residual effects lasting two days for some.

Conversely, 52 percent of patients receiving ketamine show a comparable response, with effects still detectable at seven days. So a single infusion of ketamine produces more robust and sustained improvement, but most patients continue to experience some symptoms with both drugs.

Source: IANS