A new finding reveals that by altering the micro-environment against cancer cells growth of liver tumours can be suppressed by a key molecule identified as IQGAP1. The finding offers new insight into cancer metastasis the ability of a tumour to spread from its primary site to distant organs such as the brain lung or liver. The discovery paves the way to newer therapies for preventing or treating liver metastases the major cause of death from cancer. ‘Tumour cells are intelligent - they talk to the cells in their surroundings to change the way they behave and make the environment supportive