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A deranged body clock might hold a clue to recurrent miscarriages

For long now doctors have advised women to have children before the age of thirty as it reduces complications during pregnancy and child birth and also reduces the chances of miscarriages. A new study has found out how timing affects miscarriages during pregnancy and paves new ways for fertility studies.

This researchers at the University of Warwick and UHCW have discovered how body clock genes can affect women's ability to have children. They found that for an embryo to implant in the womb, the body clock genes in the womb's linings are temporarily switched off. The timing of this event is crucial for pregnancy. (Read:Beware! These 10 things can make you infertile!)

For the study, endometrial linings of healthy women and biopsies from women had suffered recurrent miscarriages were examined. The researchers concluded that women who suffer from recurrent miscarriages were less able to regulate clock genes in the lining of the womb. This finding also provides insights into how night and shift work could affect female fertility

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It is hoped that by identifying the causes behind recurrent miscarriages, that fertility experts will be able to help more prospective parents than ever before.It could have major implications for IVF, as the findings suggest that fertility specialists could, in future, target bio-rhythms in the womb to improve the environment for implanted embryos. (Read:Pregnant women sleeping on their back risk miscarriage)

Researcher Jan Brosens said that infertility affects one in six women across the world, but the area of body clock genes has not been looked at in this detail before, adding that it's crucial during pregnancy that mothers and their babies' embryos are able to synchronise. If this fails to happen, it can cause miscarriage. Brosens noted that it can also increase the risk of complications in later stages of pregnancy such as pre-eclampsia, fetal growth restriction and pre-term birth.

Researcher Siobhan Quenby added that they believe the study has huge implications in the understanding of the body clock genes and their effect on female fertility and hope that it will increase worldwide knowledge about possible reasons for infertility and recurrent miscarriages, so that we are able to help families achieve their dream of having children.

The study appears in the Journal of the Federation of American Societies for Experimental Biology (FASEB).

Image source: Getty Images


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