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In case you have thought that platelet rich plasma (PRP) can provide relief from joint and bonepain and enhance functions of joint in degenerative joint disease, it is time you go through this new study which has shown that it does not really help to improve your joint health. This study published in Tissue Engineering, Part A revealed that platelet rich plasma does not act by promoting stem cell proliferation or improve the cartilage formation capabilities of mesenchymal stem cells (MSCs), according to a recent report by Medical Xpress.
In the article 'Effect of Platelet-rich Plasma on Chondrogenesis of Adipose and Bone Marrow-Derived Stem Cells, co-authors Jr-Jium Liou, Benjamin Rothrauff, Peter Alexander, and Rocky Tuan from University of Pittsburgh School of Medicine (PA) have derived mesenchymal stem cells (MSCs) from the fat pad of the knee and bone marrow and used them in the study.
They found that using high concentration of platelet-rich plasma for treating degenerative joints for a longer period of time can actually impair cartilage formation. This makes it less likely for chondrocyte differentiation from MSC to occur, as per the study. This, according to the experts can open new doors on developing future strategies for repairing damaged cartilage due to an injury or an ailment.
"This article presents a systematic study to elucidate the effects of PRP on the chondrogenic differentiation of adult human MSCs and its potential mechanism of action as a therapeutic adjunct for the treatment of joint diseases," reportedly said Antonios G Mikos, co-editor-in-chief of Tissue engineering.
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