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What Is Dengue? Dengue fever is a viral infection spread by mosquitos that cause high fever, headache, muscle and joint discomfort, and skin rashes. This infection is caused by four closely related serotypes of a Flaviviridae virus: DENV-1, DENV-2, DENV-3, and DENV-4, which are transmitted by the bite of Aedes mosquitos. Though these viruses are self-limiting and do not stay longer than 10 days, they can produce dengue haemorrhagic fever in extreme cases (DHF).