Topical antibiotics like erythromycin (E-Mycin, Eryc), clindamycin (BenzaClin, Duac), sulfacetamide (Klaron) and azelaic acid (Azelex) can be used. Retinoid cream or gel such as tretinoin and adapalene, are usually applied to the skin once a day. If you use a retinoid, you must avoid the sun or use a strong sunscreen because it increases your risk of getting sunburn. Besides these, your doctor may also prescribe oral antibiotics, oral contraceptives, spironolactone, cortisone injections and isotretinoin.