Nearly 100 gene variants are linked to obesity which means that your parents must have passed along some fat genes to you. But the good news is you can take a few measures to still stay in shape in spite of having those genes. A few of these smart strategies may help hack your DNA. 1. Load up on protein: A study published in the American Journal of Clinical Nutrition found that people with a variant of FTO gene linked with obesity had fewer cravings and little appetite when they were on a low-calorie diet with 25 percent protein .