Rubella or German measles is a viral infection caused by the rubella virus. The disease is often mild and affects the skin and lymph nodes.

What Is Rubella?

Rubella infection, also popularly known as German measles or three-day measles, is caused by the rubella virus and is very different from the virus that causes measles. It causes the appearance of mild rash as compared to the long-lasting inflammation in the case of measles.
Rubella is a mild disease in children that affects the skin and the lymph nodes. The condition is highly contagious and spreads quickly when a person breathes infected droplets in the air or contacts an infected person. In addition, a pregnant woman can easily pass the virus to her unborn child, which can cause congenital disabilities or miscarriage.
In earlier days, the condition appeared in children aged 5 to 9 until the vaccine against rubella became available. Currently, more cases of a rubella infection are seen to occur in non-immunized adults and less in kids.

Symptoms

When the person is infected, the virus invades throughout the body cells in 5 to 7 days, and the symptoms appear after two weeks of exposure. Therefore, the symptoms of the disease are different in different age populations.

In children, the condition is mild and causes red or pink rashes, which last for three days and spread all over the body. Swollen glands behind the neck are a prominent sign of the infection occurring in children. 

In adults, women may develop arthritis and joint pain. Moreover, pregnant women infected with the rubella virus can pass it to the foetus, which can cause death or congenital rubella syndrome in creating babies.

Other symptoms experienced due to this disease are- 


  • Headache and dizziness

  • Redness in eyes

  • Loss of appetite

  • Nausea 

  • Fever and sore throat 

  • Cough and runny nose 

Causes And Risk Factors

Causes

Rubella is contagious and is caused by a virus called rubivirus. The following are the causes of the infection:


  • It can spread quickly from one person to another through droplets when the infected person sneezes or coughs.

  • It can transmit from a pregnant mother who has been infected with the virus to her unborn child. 

  • The rubella virus affects adults due to a lack of immunization and may result in an outbreak. 


Risk Factors

A person who has not been vaccinated against the rubella virus or has not been previously infected is at higher risk for developing the infection. 

Other risk factors that contribute to the infection are- 

  • People who are coming from areas where vaccination against rubella hasn't taken place. 

  • People working with and around children

  • Healthcare workers

  • Unborn babies who contract the virus from their mothers have low immunity against the virus

  • Contact of a pregnant woman with an infected person

Prevention

Vaccination against the rubella virus plays a primary role in the prevention of the rubella virus. Besides, it helps control the spread of the virus and prevent any further complications. 

Although, it is recommended that pregnant women should not take the vaccine against the rubella virus. 

Other ways to prevent the spread of rubella:


  • Avoid sending children to school for a week after onset of rash

  • Children who contract rubella from their mother are considered contagious for one year after their birth

  • It is important to be alert if your children’s contacts have been vaccinated

Diagnosis

The diagnosis of rubella infections includes-


  • Virus detection is done with the help of polymerase chain reaction (PCR) testing using the throat, nasal or urine specimens.

  • The presence of rubella-specific antibodies can be detected using enzymes such as immunoassay.

  • In pregnant women, blood tests help to identify antibodies against the rubella virus. Positive tests results indicate that the woman is likely to be immune, whereas further diagnostic tests need to be done if the test results are negative.

  • RT-PCR test helps in the detection of specific antibodies, which allows identifying congenital rubella infection.

Treatment

Treatment options against the rubella virus include- 


  • In a woman with arthritis or joint pain, medications like non-steroidal anti-inflammatory drugs help reduce symptoms and improve the condition.

  • In pregnant women, infection depends on the stage of pregnancy at the onset of the disease. If the condition occurs before four months of pregnancy, the unborn child is at high risk of developing the rubella virus. If the infection occurs after four months, the incubation can be continued with proper management and guidance of the doctor. 

  • Rubella is mild in children, and treatment management involves monitoring fever with acetaminophen.

Lifestyle/management

One can treat rubella infection on its own over time and supportive therapy without medications. 

Antibiotic therapy does not work against the rubella virus. 

Other lifestyles measures to ease the infection-


  • Bed rest provides relief to mild symptoms 

  • Plenty of fluids

  • Self-isolation is vital to prevent spreading the disease among others in the family and outside.

Prognosis And Complications

Prognosis

The prognosis in children with congenital rubella syndrome is less likely and depends on the number of organs affected. There is a mortality risk in infants, which is associated with several other complications. Rubella occurring after childbirth is usually mild and can be treated quickly without further complications. 

In adults, appropriate treatment measures and early immunization can help in the treatment course of the disease. A woman must get vaccinated before pregnancy to avoid the infection. 

 

Complications

When a pregnant woman is infected with the rubella virus, it can lead to severe consequences. These include miscarriages, premature birth or abnormal birth effects. 

The virus is transmitted from the mother to the unborn child, who can develop congenital rubella syndrome. Complications that arise in babies are given as-. 


  • Heart problems 

  • Blood clots 

  • Hearing and speech impairment

  • Compromised learning ability 

  • Thyroid and liver problems 

  • Autism 


Other complications of the Rubella infection are- 

  • Arthritis or joint pain in a woman 

  • Infection or excessive bleeding in the brain 

  • Sleeping disorders

References


  1. Rubella, Cleaveland Clinic. Available at: https://my.clevelandclinic.org/health/diseases/17798-rubella. Accessed on May 24, 2021

  2. Rubella (German Measles), John Hopkins Medicine. Available at: https://www.hopkinsallchildrens.org/Patients-Families/Health-Library/HealthDocNew/Rubella-(German-Measles) Accessed on May 24, 2021

  3. Rubella, World Health Organisation. Available at: https://www.who.int/news-room/fact-sheets/detail/rubella Accessed on May 23, 2021

  4. Rubella, Cleaveland Clinic. Available at: https://my.clevelandclinic.org/health/diseases/17798-rubella. Accessed on May 24, 2021

  5. Rubella, National Organisation for Rare Disorders. Available at: https://rarediseases.org/rare-diseases/rubella/ Accessed on May 24, 2021

  6. Rubella (German Measles), John Hopkins Medicine. Available at: https://www.hopkinsallchildrens.org/Patients-Families/Health-Library/HealthDocNew/Rubella-(German-Measles) Accessed on May 24, 2021

  7. Rubella, BetterHealth Channel. Available at: https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/rubella#causes-of-rubella Accessed on May 23, 2021

  8. Rubella (German Measles), KidsHealth. Available at: https://kidshealth.org/en/parents/german-measles.html Accessed on May 24, 2021

  9. Rubella Symptoms and Causes, Boston Children’s Hospital. Available at: https://www.childrenshospital.org/conditions-and-treatments/conditions/r/rubella/symptoms-and-causes Accessed on May 24, 2021

  10. Rubella (German Measles, Three-day Measles), Centers for Disease Control and Prevention. Available at: https://www.cdc.gov/rubella/hcp.html Accessed on May 24, 2021

  11. Camejo Leonor M, Mendez MD. Rubella. [Updated 2020 Oct 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559040/

  12. Camejo Leonor M, Mendez MD. Rubella. [Updated 2020 Oct 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559040/

  13. Rubella (German Measles), John Hopkins Medicine. Available at: https://www.hopkinsallchildrens.org/Patients-Families/Health-Library/HealthDocNew/Rubella-(German-Measles) Accessed on May 24, 2021

  14. Rubella, Cleaveland Clinic. Available at: https://my.clevelandclinic.org/health/diseases/17798-rubella. Accessed on May 24, 2021

  15. Rubella, BetterHealth Channel. Available at: https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/rubella#causes-of-rubella Accessed on May 23, 2021

  16. Camejo Leonor M, Mendez MD. Rubella. [Updated 2020 Oct 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559040/

  17. Rubella, Cleaveland Clinic. Available at: https://my.clevelandclinic.org/health/diseases/17798-rubella. Accessed on May 24, 2021

  18. Rubella (German Measles, Three-day Measles), Centers for Disease Control and Prevention. Available at: https://www.cdc.gov/rubella/hcp.html Accessed on May 24, 2021

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