Switch to हिंदी

Health, Fitness, Beauty & Diet | Pregnancy & Parenting | Diseases & Home Remedies | TheHealthSite.com

Health, Fitness, Beauty & Diet | Pregnancy & Parenting | Diseases & Home Remedies | TheHealthSite.com

हिंदी
  • Health A-Z
  • Home Remedies
  • Diseases
    • Type 1 Diabetes
    • Type 2 Diabetes
    • Cancer
    • Heart Attack
    • Pneumonia
    • Diseases A-Z
  • Diet & Fitness
    • Weight Management
    • Exercise & Body Building
    • Diet & Recipes
    • Yoga
  • Coronavirus
  • News
  • Pregnancy
    • Conceiving
    • Infertility
    • Labour & Delivery
    • Pregnancy week-by-week
    • Breastfeeding
    • Baby Names
  • Beauty
    • Skin
    • Hair
    • Grooming
  • Photos
  • Videos
BLA21 cibil.com ageas federal zee hindustan
Home / Diseases-conditions / Multiple-sclerosis / Childhood trauma can change the trajectory of multiple sclerosis treatment in adulthood

Childhood trauma can change the trajectory of multiple sclerosis treatment in adulthood

Childhood trauma could affect the trajectory of multiple sclerosis development and response to treatment in adulthood. Read on to know more.

By: Jahnavi Sarma   | | Published: January 30, 2021 4:24 pm
Tags: Autoimmune disease  Autoimmune disorders  Multiple sclerosis cause  Multiple sclerosis treatment  
multiple sclerosis, multiple sclerosis development, multiple sclerosis treatment, multiple sclerosis risk factors, multiple sclerosis causes
Though the exact cause of this condition is not known, there are certain risk factors that can trigger flareups.

Multiple sclerosis is a progressive autoimmune disease in which the body attacks the central nervous system and strips away the protective coating around neurons. It causes a wide range of neurological symptoms including paralysis, vision loss, and mobility issues. It is a progressive condition that is debilitating and can seriously hamper the quality of life of a patient. There is no cure for the condition till date and treatment is based mostly on symptoms. But timely treatment can help patients deal with symptoms and also delay the progression of disease. Also Read - Beware! You may develop this autoimmune disorder post COVID-19 infection

Experts have doubts about what exactly causes this autoimmune condition, but they do agree that there are certain risk factors that can trigger symptoms. Now a new study from the University of Illinois at Urbana-Champaign in the US says that childhood trauma could affect the trajectory of multiple sclerosis development and response to treatment in adulthood. This study is published in the journal Nature Communications. Also Read - Lack of fatty acid in tissues can trigger multiple sclerosis. Here's how



Childhood stress may block benefits of treatment

In a study conducted on mice, the US researchers found that mice that had experienced stress when young were more likely to develop the autoimmune disorder and less likely to respond to a common treatment. According to them, mice that had experienced early-life trauma were more susceptible to experimental autoimmune encephalomyelitis (EAE) disease development. They were also more likely to suffer prolonged motor paralysis with severe neuronal damage in the central nervous system, which is caused by a heightened immune response. Also Read - Low fitness levels can up your risk of developing psoriasis

Study subjects seen to be susceptible to EAE

The mice were genetically susceptible to experimental autoimmune encephalomyelitis (EAE), the model most widely used for studying MS. The researchers watched the development and progression of EAE in mice that had been briefly separated from their mother and given a saline injection while young and compared it with mice that had not experienced the same stress of separation from their mother.

Stress hormone norepinephrine triggers EAE

The researchers traced the EAE triggers to the immune system — in particular, a receptor on immune cells that binds to the stress hormone norepinephrine. Childhood stress in the mice triggered a prolonged release of norepinephrine and the receptor was activated for long periods of time, which led the cells to decrease its expression. This weakened the immune system and made it less able to respond to the stress and inflammation of EAE. Importantly, mice that developed EAE after stress in their childhoods did not respond to treatment with interferon beta, one of the initial therapies most widely prescribed to individuals with multiple sclerosis.

A few risk factors of multiple sclerosis

Though the exact cause of this condition is not known, there are certain risk factors that can trigger flareups. It is commonly seen in people between the ages of 20 and 40 years and women are more susceptible to it than men. It may also be genetic, but experts believe that an environmental trigger is necessary for the disease to develop. Sometimes, exposure to viruses may also increase a person’s risk of developing this condition as can vitamins D and B12 deficiencies.

(With inputs from IANS)

Published : January 30, 2021 4:24 pm
Read Disclaimer

Aphantasia: This condition makes you unable to visualize images

Aphantasia: This condition makes you unable to visualize images

World Leprosy Day 2020: A few facts about this much-misunderstood disease and tips for patients

World Leprosy Day 2020: A few facts about this much-misunderstood disease and tips for patients

Please Wait. Article Loading ....

Coronavirus Updates

Coronavirus Updates

Stay Informed, Be Safe

  • New highly contagious COVID-19 variant spreading rapidly across New York
  • Indian company develops triple-combination pills for migraine, gets FDA approval
  • COVID-19 cases rising in schools across India, over 220 students test positive in 24 hrs
  • Is it safe to travel if you have got the COVID-19 vaccine? Here's what experts say
  • Canada: COVID variant cases surge as the overall number drops

Health Calculators

BMI Calculator
bmi Calculator
Ideal Body Weight
ideal body weight
Daily Calorie Intake
Daily calorie intake
Calories Burned
calories burned

Related Stories

Beware! You may develop this autoimmune disorder post COVID-19 infection

Beware! You may develop this autoimmune disorder post COVID-19 infection

Lack of fatty acid in tissues can trigger multiple sclerosis. Here's how

Lack of fatty acid in tissues can trigger multiple sclerosis. Here's how

Low fitness levels can up your risk of developing psoriasis

Low fitness levels can up your risk of developing psoriasis

Covid-19 associated Guillain Barre Syndrome: Everything you need to know

Covid-19 associated Guillain Barre Syndrome: Everything you need to know

Health News in Hindi

स्वास्थ्य मंत्रालय किया चौंकाने वाला खुलासा, कहा- “सिर्फ इन 7 राज्यों में हैं कोरोना के 89.5% नए मामले”

क्या है नेचुरोपैथी ट्रीटमेंट, जानें क्यों फेफड़ों के लिए फायदेमंद है ये तरीका

Coronavirus in MP: मध्य प्रदेश में फिर बढ़ने लगे कोरोना के मामले, पर फिलहाल लॉकडाउन नहीं लगेगा

1 स्कूल के 229 बच्चे कोरोना पॉजिटिव, जानें क्यों एक जगह पर जमा थे इतने सारे छात्र

हेयर लॉस से लेकर डायरिया तक लॉन्ग कोविड में होती हैं ये परेशानियां, जानें Long Covid क्या है और क्या हैं इसके लक्षण

Read All

Recent Posts

  • Diabetes drug metformin comes with some surprising side-effects: Here’s what you need to know
  • New highly contagious COVID-19 variant spreading rapidly across New York
  • Indian company develops triple-combination pills for migraine, gets FDA approval
  • Endometriosis: A silent killer women need to be careful of
  • COVID-19 cases rising in schools across India, over 220 students test positive in 24 hrs

About The health Site

TheHealthSite.com is India's largest health site with more than 40 lakh unique visitors per month. We focus on fitness, beauty, health, pregnancy and more.

Most popular health and wellness website in India in 2012 at the Website of the year awards.

health@corp.india.com
+91 – 22 – 6697 1234
Landline Phone number 91 – 22 – 2490 0302.

ZEE ENTERTAINMENT ENTERPRISES LTD, 18th floor, A-Wing, Marathon Futurex, N. M. Joshi Marg, Lower Parel, Mumbai, Maharashtra 400013.

Useful Links

  • Weight Loss
  • Keto Diet Tips
  • Skin Care Tips
  • Intermittent Fasting
  • Apple Cider Vinegar
  • Ashwagandha
  • Cancer
  • Pneumonia
  • Diarrhoea
  • Dengue
  • Typhoid
  • Tuberculosis
  • Chickenpox
  • Chikungunya
  • Depression
  • Hepatitis
  • Diabetes
  • Type 2 diabetes
  • Arthritis
  • Swine Flu
  • Baby Names
  • Cough and cold
  • Heart Attack
  • Breast Cancer
  • Ebola Virus
  • Dengue
  • Malaria
  • International Yoga Day
  • Hypotension
  • Heart Failure
  • Asthma
  • Brain Tumour
  • Celebrity Fitness
  • Goitre
  • HIV/AIDS

We respect your privacy

  • Disclaimer
  • Privacy Policy
  • Contact Us
  • Author Profiles

Copyright © 2021 Zee Entertainment Enterprises Limited. All rights reserved.