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Monkeypox A.2 Strain: The ICMR has analyzed the whole genome sequence of monkeypox cases detected in Kerala and Delhi from July to August 2022. The analysis, led by ICMR-NIV Pune, said that it saw three subgroups among the A.2 lineage - the first cluster aligns with Delhi (N2) and Kerala (N5) USA-2022 ON674051.1, while The second (N3) of Delhi is aligned with USA-2022 ON675438.1 and the third cluster consists of the UK, US and Thailand.
According to the study, all THD sequences from India, covering 90 to 99 per cent of the genome, belong to the A.2 lineage of clade IIB. "All retrieved sequences encircling 90% to 99% of the genome belong to the A.2 line of clade IIB from India. The A.2 mpxv line is divided into three subgroups, the first cluster being Delhi N2, Kerala N5 of USA-2022. ON674051.1, the second part of Delhi N3 is aligned with VA-2022 ON675438.1, and the third is from the UK, USA and Thailand. Current updates in the MPXV lineage have put all five sequences from Kerala as A.2.1
Clinical samples of 96 suspected monkeypox cases, i.e. oropharyngeal swab (OPS), nasopharyngeal swab (NPS), lesion crust and wound fluid from 18 states and three union territories during the period July to August 2022, 18 states and three union territories were sent from ICMR-National Institute of Virology, Pune.
Clinical samples of all cases were tested using monkeypox-specific real-time PCR. Five patients each from Delhi and Kerala were discovered positive for MPXV.
They had no international travel history, while five men had reached Kerala, India, from the United Arab Emirates (UAE).
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