Fat accumulation in the liver is common and is often seen in people with obesity or diabetes. In the worst case fatty liver can lead to cirrhosis or liver cancer. It is unusual for this to occur but in those affected symptoms often only occur at a late stage when there is no available treatment. It is difficult to predict the risk of cirrhosis although you can get some guidance in using regular blood tests that measure liver damage. Researchers from Karolinska Institutet in Sweden have found that repeated measurements of the biomarker FIB-4 in human blood every few years