Human Immunodeficiency Virus (HIV) is the virus that causes Acquired Immune Deficiency Syndrome (AIDS) which weakens the body s immune system. 90% of HIV patients suffer from some form of skin rashes in their lifetime. Skin diseases are often viewed as indicators of disease progression. The weakened immune system can lead to opportunistic infections or infections that are more rampant than normal. Patients with low cluster of differentiation (CD) counts usually have skin eruptions whereas high CD counts are associated with hypersensitive skin reactions. Infections could be generalised rashes or could be of bacterial viral fungal or of parasitic origin.