Ill-fitting shoes are mainly responsible for nasty blisters that ultimately result in nails falling off. Consider this plan from Dr Ninad Kakde for your toenail if it is a lost case. If the nail comes out in a bloody mess You need to put some pressure on the area until the bleeding subsides. Then apply some antibiotic ointment with a band-aid. Reapply the ointment and the band-aid every day after a shower until the opening has closed. Once your band-aid is on you can soak your feet in warm water and Epsom salt for 10 minutes to reduce the soreness.