Encephalitis

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Encephalitis is a disease that results in inflammation of the brain. The patient’s central nervous system is affected. While the lesser symptoms include headaches and fevers, the more severe ones cause the onset of mental issues like seizures, confusion, disorientation, tremors and hallucinations.

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What Is Encephalitis?

Encephalitis is a disease that results in inflammation of the brain. The patient’s central nervous system is affected. While the lesser symptoms include headaches and fevers, the more severe ones cause the onset of mental issues like seizures, confusion, disorientation, tremors and hallucinations. It can be caused due to bacterial or viral infections of the brain, injection of toxic substances or increased complications of an infectious disease. Infectious encephalitis is a condition that is caused due to infectious agents such as a virus, parasite, bacteria and fungi. These infectious agents cause inflammation of the brain membrane and parenchyma. These infectious agents can also call certain chronic neurological illnesses by influencing the central nervous system. Neurological deficits such as seizures, hearing or speech deficits, Loss of consciousness or altered mental status are noted in some patients. The healthcare cost remains a more significant public health issue as encephalitis is associated with mortality and morbidity. 

Types

Depending on the virus causing the disease and the mode of its transmission, encephalitis has been identified as different types:


  1. Herpes Simplex encephalitis: It is caused by the HSV-1 (Herpes simplex virus type 1) virus.

  2. Japanese encephalitis: It is caused by flavivirus, named after the yellow fever virus and was first identified in Japan. It is mainly transmitted through Culex mosquitoes.

  3. West Nile encephalitis: It is caused by a virus belonging to the Flaviviridae family and is spread through mosquitoes. Its main characteristic is high fever.

  4. Tick-borne encephalitis: Any virus that spreads through ticks to cause encephalitis is called tick-borne encephalitis.

  5. Autoimmune Encephalitis: It is caused when the body produces antibodies against healthy brain cells, which causes inflammation.

  6. Paraneoplastic Encephalomyelitis: It is caused when the antibodies created against cancer start to attack healthy brain cells.

Symptoms

The virus reaches the brain tissue and causes inflammation. It causes swelling of the brain tissue and can even destroy the neurons. Sometimes, brain haemorrhage or bleeding is also seen.

The following symptoms may occur:


  • Headache

  • Confusion

  • Disorientation

  • Stiffness in the neck and the back


Emergency symptoms of encephalitis.

  • Altered consciousness

  • Seizures

  • Weakness in hand or legs

  • There may be fever

Causes And Risk Factors

Causes

Encephalitis, in most cases, is caused by a viral infection, and there are several viruses that can cause inflammation of the brain. Some common viruses known to cause the condition include polio, rabies virus, varicella zoster (chickenpox virus), mumps and rubella. Other groups of viruses include adenovirus, cytomegalovirus, West Nile virus and echovirus.

The virus can be transmitted from one person to another through:


  • Consumption of contaminated food and water

  • Direct contact with an affected individual

  • Inhaling respiratory droplets expelled by an infected person

  • Insect bites (ticks, mosquitoes)


Other causes of encephalitis include:

  • Allergies to vaccination

  • Autoimmunity

  • Parasitic infection (roundworm, toxoplasma infection)


Risk Factors

Anybody can suffer from encephalitis, from children to elderly.’ However, the risk is greater during the first few years of life. People working in humid and warm environments may face a huge presence of mosquitoes; they are at risk of infection from arbovirus. Additionally, people with a compromised immune system and those who have an increased level of autoantibodies in them are at a greater risk.

Prevention

Prevention is the best way to control outbreaks. In India, vaccination is available against tick-borne and Japanese encephalitis and should be considered by individuals who are at a high risk. Most of these viruses are spread by mosquito bites, so control of mosquitoes breeding is very important. In India, the monsoon season is the encephalitis season. We already see outbreaks in North Bengal, and a lot of people are dying. To control death, awareness about mosquito control and prevention of encephalitis is essential. Travellers should be educated regarding the prevention of viral encephalitis. Travellers should practice protective garments and sleep under a mosquito net to prevent themselves from mosquito bites. In the areas where tick-borne infection risk is high outdoor activities should be avoided by an individual. Water should not be stored in a stagnant manner for an extended period; insecticide spraying should be done regularly.

Diagnosis

Emergency symptoms form the basis of suspected encephalitis. But to diagnose its root cause, different tests might be needed. ‘Diagnosis involves a combination of clinical examination with the help of brain scans, mainly magnetic resonance imaging (MRI). We also need an electroencephalogram (EEG) along with the study of cerebrospinal fluid (CSF) obtained through a lumbar puncture.

Some viral encephalitis like Herpes Simplex encephalitis and Japanese encephalitis do have definitive diagnostic tests. Some of them can be detected by serological testing, where the presence of antibodies against the virus is detected. The recent viral encephalitis caused by the West Nile virus can be diagnosed in some labs in India. For autoimmune encephalitis, there are different blood tests and CSF tests.

MRI and CT scan help in excluding the risk of uncal herniation before performing a lumbar puncture. CT scan detects low-density lesions in temporal lobes, which appear three to five days after the infection. Cerebrospinal fluid will evaluate average glucose, moderate lymphocytosis and moderately elevated protein in the body. EEG is used mainly in detecting abnormalities in patients with a history of seizures. Three types of EEG patterns are observed in encephalitis- Diffuse continuous delta activity, diffuse delta activity with spikes and alpha comma activity.

Treatment

The goal of the treatment is to provide supportive care and help the body fight infection. Treatment is usually as per the symptoms (symptomatic). Reliably tested, specific drugs against viruses (antiviral agents) are few in number and are used with limited success in the treatment of viral infection, with the exception of herpes simplex encephalitis, which is treated with acyclovir.’ Acyclovir has shown promising activity in reducing morbidity and mortality and reducing the progression of long-term cognitive and behavioural impairment of HSV encephalitis. Acyclovir should be prescribed in the dose of 10 to 15mg/kg Intravenously every eight hours for 10 to 14 days.
In patients who are very sick, supportive treatment such as mechanical ventilation is equally important. Most of these patients require care in an ICU setting. Corticosteroids (e.g., methylprednisolone) are used to reduce brain swelling and inflammation. Intracranial pressure should be monitored in patients with viral encephalitis. Poor prognosis is detected in patients with increased intracranial pressure. Management of seizures is done with phenytoin or valproic acid. Status epilepticus patients should be managed with benzodiazepines, psychotics for behavioural alterations, and sedatives may be needed for irritability or restlessness.
In patients with autoimmune encephalitis and paraneoplastic encephalomyelitis, the treatment can be corticosteroids, immunoglobulin therapy, plasmapheresis, or rituximab.

Lifestyle/management

An individual experiencing encephalitis related complications should resort to the following lifestyle management strategies:


  1. Physical therapy should be practised to improve balance, flexibility, motor coordination, mobility and strength of muscles.

  2. Speech therapy will help in maintaining coordination and control of muscles to produce speech.

  3. Psychotherapy is an effective way of coping with new behavioural skills and strategies in treating mood disorders or personality changes.

  4. Occupational therapy is the use of adaptive products to enhance everyday skills and activities.

Prognosis And Complications

Prognosis

The majority of patients recover from viral encephalitis without any complications. However, the symptomatic patients have trouble concentrating, memory loss or behavioural and speech disorders. Paediatric patients develop changes in behaviour and seizures following viral encephalitis. Microcephaly may occur as a complication of zika virus infection in pregnant women. Frequently reported complication after viral encephalitis is seizures which are reported in 10 to 20% of patients.

Complications

 Viral encephalitis is associated with complications in the patients experiencing viral encephalitis symptoms for an extended period. Complications of viral encephalitis are related to different systems in the body. Early diagnosis of the complications and prompt treatment can prevent the progression of complications can improve the quality of life of the patient. some of the complications of viral encephalitis are as follows-


  • Mood and behaviour changes

  • Extrapyramidal symptoms (Japanese Encephalitis)

  • Encephalopathy

  • Flaccid paralysis

  • Mononeuropathy

  • SIADH (St Louis’ encephalitis)

  • Impairment in intelligence

  • Residual neurological deficits

  • Hyponatremia (especially St. Louis encephalitis)

References


  1. British Medical Journal (BMJ). Systematic review of rehabilitation intervention outcomes of adult and paediatric patients with infectious encephalitis. Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961616/. Accessed on April 3, 2021 

  2. Stat Pearls. Viral Encephalitis [Updated on August 10, 2020] Available at https://www.ncbi.nlm.nih.gov/books/NBK470162/. Accessed on April 3, 2021 

  3. NIH. Autoimmune encephalitis. Available at: https://rarediseases.info.nih.gov/diseases/11979/autoimmune-encephalitis. Accessed on Jun 21, 2021.

  4. Lancaster E. The Diagnosis and Treatment of Autoimmune Encephalitis. J Clin Neurol. 2016 Jan;12(1):1-13. 

  5. NIH. Paraneoplastic Syndromes Information Page. Available at: https://www.ninds.nih.gov/Disorders/All-Disorders/Paraneoplastic-Syndromes-Information-Page. Accessed on Jun 21, 2021.

  6. Grisold W, et al. Current approaches to the treatment of paraneoplastic encephalitis. Ther Adv Neurol Disord. 2011 Jul;4(4):237-48.

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